Journal of Applied Physiology
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J Appl Physiol 91: 2451-2458, 2001;
8750-7587/01 $5.00
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Vol. 91, Issue 6, 2451-2458, December 2001

Cervical spinal cord injury alters the pattern of breathing in anesthetized rats

Francis J. Golder1, Paul J. Reier2, Paul W. Davenport1, and Donald C. Bolser1

1 Department of Physiological Sciences, College of Veterinary Medicine, and 2 Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida 32610

The mechanisms by which chronic cervical spinal cord injury alters respiratory function and plasticity are not well understood. We speculated that spinal hemisection at C2 would alter the respiratory pattern controlled by vagal mechanisms. Expired volume (VE) and respiratory rate (RR) were measured in anesthetized control and C2-hemisected rats at 1 and 2 mo postinjury. C2 hemisection altered the pattern of breathing at both postinjury time intervals. Injured rats utilized a higher RR and lower VE to maintain the same minute ventilation as control rats. After bilateral vagotomy, the pattern of breathing in injured rats was not different from controls. The frequency of augmented breaths was higher in injured rats at 2 mo postinjury before vagotomy; however, the VE of augmented breaths was not different between groups. In conclusion, C2 hemisection alters the pattern of breathing at 1 and 2 mo postinjury via vagal mechanisms.

augmented breath; vagal afferents


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