Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 91: 2334-2341, 2001;
8750-7587/01 $5.00
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Vol. 91, Issue 5, 2334-2341, November 2001

Effect of weight bearing on recovery from nerve injury in skeletal muscle

Tetsuya Matsuura1, Takaaki Ikata1, Shinjiro Takata1, Shinji Kashiwaguchi1, Mineo Niwa2, Takayuki Sogabe3, and Keiko Koga3

1 Department of Orthopedic Surgery, School of Medicine, University of Tokushima, Tokushima 770-8503; 2 Institute for Medicinal Resources, University of Tokushima, Tokushima 770-8505; and 3 Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima 771-0192, Japan

We examined the effect of weight bearing (WB) on muscle recovery after nerve injury. Rats were housed in individual cages for 2 wk under WB or hindlimb suspension (HS) after being subjected to sciatic nerve compression for 1 wk. Sham operated on rats served as controls (sham group). We used 31P- and 19F-nuclear magnetic resonance spectroscopy combined with histochemical, physiological, and biochemical techniques to assess the outcome in the three groups. Creatine kinase-BB (CK-BB) mRNA levels expression, CK activity, and type I fiber density in the WB group were elevated compared with those in the HS group. In addition, sciatic functional index, tetanic tension, energy state, and local circulation dynamics of the WB group were greater than those of the HS group. These results suggested that WB plays an important role in muscle regeneration, inhibits the reduction of CK activity, and facilitates the activation of neural recovery, energy state, and local circulation dynamics.

weight bearing; sciatic nerve compression; energy state


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