Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 91: 2289-2297, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feroah, T. R.
Right arrow Articles by Rice, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feroah, T. R.
Right arrow Articles by Rice, T.
Vol. 91, Issue 5, 2289-2297, November 2001

Negative pressure effects on mechanically opposing pharyngeal muscles in awake and sleeping goats

Thom R. Feroah1,2, H. V. Forster1, L. Pan3, N. E. Schlick1, Paul Martino1, and Tom Rice2

Departments of 1 Physiology and 2 Pediatrics, Medical College of Wisconsin and Zablocki Veterans Affairs, Milwaukee 53226; and 3 Department of Physical Therapy, Marquette University, Milwaukee, Wisconsin 53201

Our aim was to investigate the effects of the negative pressure reflex on mechanically opposing pharyngeal muscles during wakefulness, slow-wave sleep (SWS), and rapid eye movement (REM) sleep. In four goats with isolated upper airways, we measured tracheal airflow and electrical activity of the thyropharyngeus (TP; constricting), the stylopharyngeus (SP; dilating), and the diaphragm (Dia). In the wakefulness state in response to negative pressure tests, TP decreased (65%), SP increased (198%), and tidal volume (VT) (66%) and rate of rise of Dia (Diaslope, 69%) decreased (P < 0.02). Similarly, during SWS, the negative pressure response of TP (31%), VT (61%), and Diaslope (60%) decreased, whereas SP (113%) increased, relative to SWS control (P < 0.02). In REM sleep, the negative pressure response by TP and SP were small, whereas both VT (38%) and Diaslope (24%) were greatly decreased (P < 0.02) compared with REM control. Inspiratory duration remained unchanged in response to negative pressure tests in all states. These data provide evidence that mechanically opposing inspiratory and expiratory pharyngeal muscles are reciprocally controlled and their response to negative pressure are state dependent.

slow-wave sleep; rapid eye movement sleep; electromyography; sleep apnea; upper airways; thyropharyngeus; stylopharyngeus


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
K. D. O'Halloran and G. E. Bisgard
Upper airway pressure-flow relationships and pharyngeal constrictor EMG activity during prolonged expiration in awake goats
J Appl Physiol, July 1, 2008; 105(1): 100 - 108.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. R. Schwartz, S. P. Patil, A. M. Laffan, V. Polotsky, H. Schneider, and P. L. Smith
Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches
Proceedings of the ATS, February 15, 2008; 5(2): 185 - 192.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. R. Feroah, H. V. Forster, C. G. Fuentes, P. Martino, M. Hodges, J. Wenninger, L. Pan, and T. Rice
Perturbations in three medullary nuclei enhance fractionated breathing in awake goats
J Appl Physiol, April 1, 2003; 94(4): 1508 - 1518.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online