| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Exercise and Sport Sciences and Physiology and the Center for Exercise Science, University of Florida, Gainesville, Florida 32611
These experiments
examined the independent effects of short-term exercise and heat stress
on myocardial responses during in vivo ischemia-reperfusion
(I/R). Female Sprague-Dawley rats (4 mo old) were randomly
assigned to one of four experimental groups: 1) control,
2) 3 consecutive days of treadmill exercise [60 min/day at
60-70% maximal O2 uptake
(
O2 max)], 3) 5 consecutive days of treadmill exercise (60 min/day at 60-70%
O2 max), and 4) whole body
heat stress (15 min at 42°C). Twenty-four hours after heat stress or
exercise, animals were anesthetized and mechanically ventilated, and
the chest was opened by thoracotomy. Coronary occlusion was maintained
for 30-min followed by a 30-min period of reperfusion. Compared with
control, both heat-stressed animals and exercised animals (3 and 5 days) maintained higher (P < 0.05) left ventricular
developed pressure (LVDP), maximum rate of left venticular pressure
development (+dP/dt), and maximum rate of left ventricular
pressure decline (
dP/dt) at all measurement periods during
both ischemia and reperfusion. No differences existed between heat-stressed and exercise groups in LVDP, +dP/dt,
and dP/dt at any time during ischemia or
reperfusion. Both heat stress and exercise resulted in an increase
(P < 0.05) in the relative levels of left ventricular
heat shock protein 72 (HSP72). Furthermore, exercise (3 and 5 days)
increased (P < 0.05) myocardial glutathione levels and
manganese superoxide dismutase activity. These data indicate that
3-5 consecutive days of exercise improves myocardial contractile
performance during in vivo I/R and that this exercise-induced myocardial protection is associated with an increase in both myocardial HSP72 and cardiac antioxidant defenses.
endurance exercise; heart; reactive oxygen species; heat shock proteins; lipid peroxidation; antioxidant enzymes
This article has been cited by other articles:
|
|
 |
|
  K. Y. Wonders, D. S. Hydock, C. M. Schneider, and R. Hayward Acute Exercise Protects Against Doxorubicin Cardiotoxicity Integr Cancer Ther, September 1, 2008; 7(3): 147 - 154. [Abstract] [PDF]
|
|
|
|
 |
|
 J. P. French, K. L. Hamilton, J. C. Quindry, Y. Lee, P. A. Upchurch, and S. K. Powers Exercise-induced protection against myocardial apoptosis and necrosis: MnSOD, calcium-handling proteins, and calpain FASEB J, August 1, 2008; 22(8): 2862 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Pitsavos, S. A. Kavouras, D. B. Panagiotakos, S. Arapi, C. A. Anastasiou, S. Zombolos, P. Stravopodis, Y. Mantas, Y. Kogias, A. Antonoulas, et al. Physical Activity Status and Acute Coronary Syndromes Survival: The GREECS (Greek Study of Acute Coronary Syndromes) Study J. Am. Coll. Cardiol., May 27, 2008; 51(21): 2034 - 2039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Chicco, S. A. McCune, C. A. Emter, G. C. Sparagna, M. L. Rees, D. A. Bolden, K. D. Marshall, R. C. Murphy, and R. L. Moore Low-Intensity Exercise Training Delays Heart Failure and Improves Survival in Female Hypertensive Heart Failure Rats Hypertension, April 1, 2008; 51(4): 1096 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Kavazis, J. M. McClung, D. A. Hood, and S. K. Powers Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H928 - H935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Brown, M. S. Johnson, C. J. Armstrong, J. M. Lynch, N. M. Caruso, L. B. Ehlers, M. Fleshner, R. L. Spencer, and R. L. Moore Short-term treadmill running in the rat: what kind of stressor is it? J Appl Physiol, December 1, 2007; 103(6): 1979 - 1985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Quindry, K. L. Hamilton, J. P. French, Y. Lee, Z. Murlasits, N. Tumer, and S. K. Powers Exercise-induced HSP-72 elevation and cardioprotection against infarct and apoptosis J Appl Physiol, September 1, 2007; 103(3): 1056 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Thorp, J. V. Haist, J. Leppard, K. J. Milne, M. Karmazyn, and E. G. Noble Exercise training improves myocardial tolerance to ischemia in male but not in female rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R363 - R371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Akita, H. Otani, S. Matsuhisa, S. Kyoi, C. Enoki, R. Hattori, H. Imamura, H. Kamihata, Y. Kimura, and T. Iwasaka Exercise-induced activation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2051 - H2059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Dawson, R. Shave, G. Whyte, D. Ball, C. Selmer, O. Jans, N. H. Secher, and K. P. George Cardiovascular Control: Preload maintenance and the left ventricular response to prolonged exercise in men Exp Physiol, March 1, 2007; 92(2): 383 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Taylor, M. E. Olsen, and J. W. Starnes Improved postischemic function following acute exercise is not mediated by nitric oxide synthase in the rat heart Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H601 - H607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. O. Reger, M. F. Barbe, M. Amin, B. F. Renna, L. A. Hewston, S. M. MacDonnell, S. R. Houser, and J. R. Libonati Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension J Appl Physiol, February 1, 2006; 100(2): 541 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Libonati, Z. V. Kendrick, and S. R. Houser Sprint training improves postischemic, left ventricular diastolic performance J Appl Physiol, December 1, 2005; 99(6): 2121 - 2127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Starnes, A. M. Choilawala, R. P. Taylor, M. J. Nelson, and M. D. Delp Myocardial Heat Shock Protein 70 Expression in Young and Old Rats After Identical Exercise Programs J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2005; 60(8): 963 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Chicco, C. M. Schneider, and R. Hayward Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R424 - R431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Moran, I. Blazquez, A. Saborido, and A. Megias Antioxidants and ecto-5'-nucleotidase are not involved in the training-induced cardioprotection against ischaemia-reperfusion injury Exp Physiol, July 1, 2005; 90(4): 507 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A Brown, J. M Lynch, C. J Armstrong, N. M Caruso, L. B Ehlers, M. S Johnson, and R. L Moore Susceptibility of the heart to ischaemia-reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat J. Physiol., April 15, 2005; 564(2): 619 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Lennon, J. C. Quindry, K. L. Hamilton, J. P. French, J. Hughes, J. L. Mehta, and S. K. Powers Elevated MnSOD is not required for exercise-induced cardioprotection against myocardial stunning Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H975 - H980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Lennon, J. Quindry, K. L. Hamilton, J. French, J. Staib, J. L. Mehta, and S. K. Powers Loss of exercise-induced cardioprotection after cessation of exercise J Appl Physiol, April 1, 2004; 96(4): 1299 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Demirel, K. L. Hamilton, R. A. Shanely, N. Tumer, M. J. Koroly, and S. K. Powers Age and attenuation of exercise-induced myocardial HSP72 accumulation Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1609 - H1615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Starnes, R. P. Taylor, and Y. Park Exercise improves postischemic function in aging hearts Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H347 - H351. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
