Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 91: 2182-2189, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tesfaigzi, Y.
Right arrow Articles by Conn, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tesfaigzi, Y.
Right arrow Articles by Conn, C. A.
Vol. 91, Issue 5, 2182-2189, November 2001

Bcl-2 mediates sex-specific differences in recovery of mice from LPS-induced signs of sickness independent of IL-6

Yohannes Tesfaigzi1, Karin Rudolph1, Mark J. Fischer1, and Carole A. Conn1,2

1 Lovelace Respiratory Research Institute, Albuquerque 87185; and 2 Department of Nutrition, University of New Mexico, Albuquerque, New Mexico 87131

Chronic pulmonary diseases are more common in boys than in girls. Therefore, we investigated the differences in signs of sickness in male and female mice that were exposed to lipopolysaccharide (LPS) by intranasal instillation. Because apoptosis is important in the resolution of inflammation, we tested the hypothesis that reduced levels of Bcl-2, a regulator of apoptosis, may play a role in gender-specific differences in response to inflammation. Bcl-2 wild-type (+/+) female mice recovered from an LPS-induced drop in body temperature and loss in body weight significantly faster than male (+/+) mice. Female heterozygous (+/-) mice showed reduced Bcl-2 levels and exhibited a slower recovery than female (+/+) mice that was similar to the recovery pattern in male (+/+) and (+/-) mice. Interleukin-6 (IL-6) activity levels in the bronchoalveolar lavage fluid were higher in male than in female mice but were not different between (+/+) and (+/-) mice. We conclude that Bcl-2 plays a role in mediating the faster recovery of female (+/+) mice from LPS-induced signs of sickness independent of IL-6. These studies indicate that apoptotic mechanisms may be involved in gender-specific differences in chronic pulmonary diseases.

apoptosis; hypothermia; cytokines; inflammation; mucus


This article has been cited by other articles:


Home page
 BloodHome page
R. A. Dean, J. H. Cox, C. L. Bellac, A. Doucet, A. E. Starr, and C. M. Overall
Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx
Blood, October 15, 2008; 112(8): 3455 - 3464.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. A. Carey, J. W. Card, J. W. Voltz, D. R. Germolec, K. S. Korach, and D. C. Zeldin
The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies
Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L272 - L278.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. W. Card, M. A. Carey, J. A. Bradbury, L. M. DeGraff, D. L. Morgan, M. P. Moorman, G. P. Flake, and D. C. Zeldin
Gender Differences in Murine Airway Responsiveness and Lipopolysaccharide-Induced Inflammation
J. Immunol., July 1, 2006; 177(1): 621 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. F. Harris, M. J. Fischer, J. R. Hotchkiss, B. P. Monia, S. H. Randell, J. R. Harkema, and Y. Tesfaigzi
Bcl-2 Sustains Increased Mucous and Epithelial Cell Numbers in Metaplastic Airway Epithelium
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 764 - 772.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
B. Burke, A. Pridmore, N. Harraghy, A. Collick, J. Brown, and T. Mitchell
Transgenic Mice Showing Inflammation-Inducible Overexpression of Granulocyte Macrophage Colony-Stimulating Factor
Clin. Vaccine Immunol., May 1, 2004; 11(3): 588 - 598.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online