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-adrenergic blockade
1 Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309; 2 Palo Alto Veterans Affairs Health Care System, Palo Alto, California 94304; and 3 University of Colorado Health Sciences Center, Denver, Colorado 80262
Interleukin-6
(IL-6), an important cytokine involved in a number of biological
processes, is consistently elevated during periods of stress. The
mechanisms responsible for the induction of IL-6 under these conditions
remain uncertain. This study examined the effect of 
-adrenergic
blockade on the IL-6 response to acute and chronic high-altitude
exposure in women both at rest and during exercise. Sixteen healthy,
eumenorrheic women (aged 23.2 ± 1.4 yr) participated in the
study. Subjects received either -adrenergic blockade (prazosin, 3 mg/day) or a placebo in a double-blinded, randomized fashion.
Subjects participated in submaximal exercise tests at sea level and on
days 1 and 12 at altitude (4,300 m). Resting
plasma and 24-h urine samples were collected throughout the duration of
the study. At sea level, no differences were found at rest for plasma
IL-6 between groups (1.5 ± 0.2 and 1.2 ± 0.3 pg/ml for
placebo and blocked groups, respectively). On acute ascent to altitude,
IL-6 levels increased significantly in both groups compared with
sea-level values (57 and 84% for placebo and blocked groups,
respectively). After 12 days of acclimatization, IL-6 levels remained
elevated for placebo subjects; however, they returned to sea-level
values in the blocked group. -Adrenergic blockade significantly
lowered the IL-6 response to exercise both at sea level (46%) and at
altitude (42%) compared with placebo. A significant correlation
(P = 0.004) between resting IL-6 and urinary
norepinephrine excretion rates was found over the course of time while
at altitude. In conclusion, the results indicate a role for
-adrenergic regulation of the IL-6 response to the stress of both
short-term moderate-intensity exercise and hypoxia.
hypoxia; catecholamines; norepinephrine; epinephrine; cytokines
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