Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 91: 2047-2054, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schuster, D. P.
Right arrow Articles by Stephenson, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schuster, D. P.
Right arrow Articles by Stephenson, A.
Vol. 91, Issue 5, 2047-2054, November 2001

Effect of endotoxin on oleic acid lung injury does not depend on priming

Daniel P. Schuster1, James K. Kozlowski1, Tim McCarthy1, Jason Morrow3, and Alan Stephenson2

1 Washington University School of Medicine, St. Louis 63110; 2 St. Louis University, St. Louis, Missouri 63103; and 3 Vanderbilt University School of Medicine, Nashville, Tennessee 37240

Recent studies have demonstrated significant synergistic physiological and biochemical effects between low-dose endotoxin (Etx) administration and oleic acid (OA)-induced canine lung injury. To evaluate whether this interaction depends on Etx priming of some key cell population, we compared the effects of giving low-dose Etx both after as well as before inducing lung injury with OA. In addition to hemodynamic and blood-gas measurements, positron emission tomographic imaging was used to measure edema accumulation and intrapulmonary blood flow distribution. Biochemical measurements of the stable metabolites of prostacyclin and thromboxane were obtained as well as measurements of isoprostanes and reactive sulfhydryls as evidence for possible concomitant oxidant production. We found that the physiological and biochemical effects of low-dose Etx developed 30-45 min after its administration, regardless of whether Etx was administered before or after OA. No increase in either isoprostane or reactive sulfhydryl production after Etx and/or OA was detected. These data suggest that the synergistic effect of low-dose Etx and OA-induced lung injury is not due to a priming effect of Etx.

positron emission tomography; pulmonary edema


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Matute-Bello, C. W. Frevert, and T. R. Martin
Animal models of acute lung injury
Am J Physiol Lung Cell Mol Physiol, September 1, 2008; 295(3): L379 - L399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Z. Zhou, J. Kozlowski, and D. P. Schuster
Physiologic, Biochemical, and Imaging Characterization of Acute Lung Injury in Mice
Am. J. Respir. Crit. Care Med., August 1, 2005; 172(3): 344 - 351.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. J. McVerry, X. Peng, P. M. Hassoun, S. Sammani, B. A. Simon, and J. G. N. Garcia
Sphingosine 1-Phosphate Reduces Vascular Leak in Murine and Canine Models of Acute Lung Injury
Am. J. Respir. Crit. Care Med., November 1, 2004; 170(9): 987 - 993.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
T. Geiser
The Role of Neutrophils and Neutrophil Products in Pulmonary Hemodynamics of Endotoxin in Oleic Acid-Induced Lung Injury
Anesth. Analg., February 1, 2004; 98(2): 281 - 282.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
L. L. Hill, D. L. Chen, J. Kozlowski, and D. P. Schuster
Neutrophils and Neutrophil Products Do Not Mediate Pulmonary Hemodynamic Effects of Endotoxin on Oleic Acid-Induced Lung Injury
Anesth. Analg., February 1, 2004; 98(2): 452 - 457.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online