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Departments of 1 Medicine and 2 Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester 14627; 3 Department of Physiology, School of Medicine, State University of New York, Buffalo, New York 14214; and 4 Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104
Measurements of
nitric oxide (NO) pulmonary diffusing capacity
(DLNO) multiplied by alveolar NO partial
pressure (PANO) provide values for alveolar NO
production (
ANO). We evaluated
applying a rapidly responding chemiluminescent NO analyzer to measure
DLNO during a single, constant exhalation
(DexNO) or by rebreathing (DrbNO). With
the use of an initial inspiration of 5-10 parts/million of NO with
a correction for the measured NO back pressure, DexNO in
nine healthy subjects equaled 125 ± 29 (SD)
ml · min
1 · mmHg1 and
DrbNO equaled 122 ± 26 ml · min1 · mmHg1. These
values were 4.7 ± 0.6 and 4.6 ± 0.6 times greater,
respectively, than the subject's single-breath carbon monoxide
diffusing capacity (DsbCO). Coefficients of variation were
similar to previously reported breath-holding, single-breath
measurements of DsbCO. PANO
measured in seven of the subjects equaled 1.8 ± 0.7 mmHg × 106 and resulted in ANO of
0.21 ± 0.06 µl/min using DexNO and 0.20 ± 0.6 µl/min with DrbNO. DexNO remained constant at
end-expiratory oxygen tensions varied from 42 to 682 Torr. Decreases in
lung volume resulted in falls of DexNO and
DrbNO similar to the reported effect of volume changes on
DsbCO. These data show that rapidly responding
chemiluminescent NO analyzers provide reproducible measurements of
DLNO using single exhalations or rebreathing
suitable for measuring ANO.
alveoli; rebreathing
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