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J Appl Physiol 91: 1886-1892, 2001;
8750-7587/01 $5.00
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Vol. 91, Issue 4, 1886-1892, October 2001

HIGHLIGHTED TOPICS
Genome and Hormones: Gender Differences in Physiology
Selected Contribution: Estrogen receptor-alpha antisense decreases brain estrogen receptor levels and affects ventilation in male and female rats

Shashita R. Inamdar, Kathleen M. Eyster, and Evelyn H. Schlenker

Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota 57069

We hypothesized that administration of an antisense oligodeoxynucleotide (ODN) to estrogen receptor (ER)-alpha mRNA decreases the ER protein in the neonatal rat brain, alters the sex-specific ventilatory responses to aspartic acid in rats, and counteracts the effects of testosterone proportionate (TP) in females. One-day-old rat pups were injected intraventricularly with vehicle, antisense ER ODN, or scrambled ODN control. Additional groups of females received TP or vehicle and one of the three treatments. Brain ER protein levels were decreased by 65% at 6 h and 35% at 24 h after antisense ODN. Aspartic acid decreased ventilation in all groups of weanling males and females except ER ODN-treated females and TP-vehicle-treated females. Aspartic acid decreased ventilation in all groups of adult females except those given TP and in males. Weanling ER ODN-treated rats were shorter and weighed less than controls. Only adult ER ODN-treated males exhibited these traits. Thus neonatal ER affects aspartic acid modulation of breathing and body growth in a sex-specific and developmental manner.

cortex; hypothalamus; brain stem; N-methyl-D-aspartic receptor; aspartic acid; body weight; length


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