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J Appl Physiol 91: 1808-1813, 2001;
8750-7587/01 $5.00
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Vol. 91, Issue 4, 1808-1813, October 2001

TGF-beta 1 gene-race interactions for resting and exercise blood pressure in the HERITAGE Family Study

Miguel A. Rivera1, Marcos Echegaray1, Tuomo Rankinen2, Louis Pérusse3, Treva Rice4, Jacques Gagnon3, Arthur S. Leon5, James S. Skinner6, Jack H. Wilmore7, D. C. Rao4,8, and Claude Bouchard2

1 Departments of Physiology and Physical Medicine, Rehabilitation and Sports Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936; 2 Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808-4124; 3 Physical Activity Sciences Laboratory, Laval University, Québec, Canada G1K 7P4; 4 Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110; 5 School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis, Minnesota 55455; 6 Department of Kinesiology, Indiana University, Bloomington, Indiana 47405; 7 Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77843-4243; and 8 Departments of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110

We examined the possible association between a transforming growth factor (TGF)-beta 1 gene polymorphism in codon 10 and blood pressure (BP) at rest, in acute response to exercise in the pretrained (sedentary) and trained states, as well as in its training response (Delta ) to 20 wk of endurance exercise. Subjects were 257 black and 480 white, healthy sedentary normotensive subjects from the HERITAGE Family Study. The polymorphism was detected by polymerase chain reaction and digestion with the Msp A1 I endonuclease yielding a wild (leucine-10) and a mutant (proline-10) allele. Resting and exercise [50 W plus 60, 80, and 100% maximal oxygen consumption (VO2 max)] BP were determined before and after training. Significant (P < 0.05) race-genotype interactions were found for systolic (S) BP in both the sedentary and trained states. Among whites but not in blacks, the TGF-beta 1 genotypes were significantly (P < 0.05) associated with sedentary-state SBP at rest, at 50 W, and at 60 and 100% VO2 max as well as with trained-state SBP at rest and at 80 and 100% VO2 max. The leucine-10 homozygotes had significantly (P < 0.05) lower SBP than proline-10 homozygotes. Delta BP was not significantly associated with genotype. These results support the hypothesis of an association between the TGF-beta 1 marker in codon 10 and SBP at rest and in response to acute exercise in whites but not in blacks.

genetics; polymerase chain reaction; genetic variation; DNA; endurance; transforming growth factor-beta 1


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