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1 Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231; and 2 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390
To identify
whether muscle metaboreceptor stimulation alters baroreflex control of
muscle sympathetic nerve activity (MSNA), MSNA, beat-by-beat arterial
blood pressure (Finapres), and electrocardiogram were recorded in 11 healthy subjects in the supine position. Subjects performed 2 min of isometric handgrip exercise at 40% of maximal voluntary
contraction followed by 2.5 min of posthandgrip muscle ischemia. During muscle ischemia, blood pressure was
lowered and then raised by intravenous bolus infusions of sodium
nitroprusside and phenylephrine HCl, respectively. The slope of
the relationship between MSNA and diastolic blood pressure was more
negative (P < 0.001) during posthandgrip muscle
ischemia (
201.9 ± 20.4 units · beat
1 · mmHg1) when
compared with control conditions (142.7 ± 17.3 units · beat1 · mmHg1). No
significant change in the slope of the relationship between heart rate
and systolic blood pressure was observed. However, both curves shifted
during postexercise ischemia to accommodate the elevation in
blood pressure and MSNA that occurs with this condition. These data
suggest that the sensitivity of baroreflex modulation of MSNA is
elevated by muscle metaboreceptor stimulation, whereas the sensitivity
of baroreflex of modulate heart rate is unchanged during posthandgrip
muscle ischemia.
metaboreceptor; baroreflex sensitivity; heart rate; exercise
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