| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231; and 2 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390
To identify
whether muscle metaboreceptor stimulation alters baroreflex control of
muscle sympathetic nerve activity (MSNA), MSNA, beat-by-beat arterial
blood pressure (Finapres), and electrocardiogram were recorded in 11 healthy subjects in the supine position. Subjects performed 2 min of isometric handgrip exercise at 40% of maximal voluntary
contraction followed by 2.5 min of posthandgrip muscle ischemia. During muscle ischemia, blood pressure was
lowered and then raised by intravenous bolus infusions of sodium
nitroprusside and phenylephrine HCl, respectively. The slope of
the relationship between MSNA and diastolic blood pressure was more
negative (P < 0.001) during posthandgrip muscle
ischemia (
201.9 ± 20.4 units · beat
1 · mmHg1) when
compared with control conditions (142.7 ± 17.3 units · beat1 · mmHg1). No
significant change in the slope of the relationship between heart rate
and systolic blood pressure was observed. However, both curves shifted
during postexercise ischemia to accommodate the elevation in
blood pressure and MSNA that occurs with this condition. These data
suggest that the sensitivity of baroreflex modulation of MSNA is
elevated by muscle metaboreceptor stimulation, whereas the sensitivity
of baroreflex of modulate heart rate is unchanged during posthandgrip
muscle ischemia.
metaboreceptor; baroreflex sensitivity; heart rate; exercise
This article has been cited by other articles:
|
|
 |
|
  R. C. Drew, D. B. McIntyre, C. Ring, and M. J. White Local metabolite accumulation augments passive muscle stretch-induced modulation of carotid-cardiac but not carotid-vasomotor baroreflex sensitivity in man Exp Physiol, September 1, 2008; 93(9): 1044 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ichinose, M. Saito, N. Fujii, T. Ogawa, K. Hayashi, N. Kondo, and T. Nishiyasu Modulation of the control of muscle sympathetic nerve activity during incremental leg cycling J. Physiol., June 1, 2008; 586(11): 2753 - 2766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Fisher, C. N. Young, and P. J. Fadel Effect of muscle metaboreflex activation on carotid-cardiac baroreflex function in humans Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2296 - H2304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cui, V. Mascarenhas, R. Moradkhan, C. Blaha, and L. I. Sinoway Effects of muscle metabolites on responses of muscle sympathetic nerve activity to mechanoreceptor(s) stimulation in healthy humans Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R458 - R466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gujic, D. Laude, A. Houssiere, S. Beloka, J.-F. Argacha, D. Adamopoulos, O. Xhaet, J.-L. Elghozi, and P. van de Borne Differential effects of metaboreceptor and chemoreceptor activation on sympathetic and cardiac baroreflex control following exercise in hypoxia in human J. Physiol., November 15, 2007; 585(1): 165 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cui, S. Durand, and C. G. Crandall Baroreflex control of muscle sympathetic nerve activity during skin surface cooling J Appl Physiol, October 1, 2007; 103(4): 1284 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ichinose, S. Koga, N. Fujii, N. Kondo, and T. Nishiyasu Modulation of the spontaneous beat-to-beat fluctuations in peripheral vascular resistance during activation of muscle metaboreflex Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H416 - H424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Fu, R. P. Shook, K. Okazaki, J. L. Hastings, S. Shibata, C. L. Conner, M. D. Palmer, and B. D. Levine Vasomotor sympathetic neural control is maintained during sustained upright posture in humans J. Physiol., December 1, 2006; 577(2): 679 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, C. Blaha, R. Moradkhan, K. S. Gray, and L. I. Sinoway Muscle sympathetic nerve activity responses to dynamic passive muscle stretch in humans J. Physiol., October 15, 2006; 576(2): 625 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ichinose, M. Saito, N. Kondo, and T. Nishiyasu Time-dependent modulation of arterial baroreflex control of muscle sympathetic nerve activity during isometric exercise in humans Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1419 - H1426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ichinose and T. Nishiyasu Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1532 - H1538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gherghel, S. L. Hosking, and I. A. Cunliffe Abnormal Systemic and Ocular Vascular Response to Temperature Provocation in Primary Open-Angle Glaucoma Patients: A Case for Autonomic Failure? Invest. Ophthalmol. Vis. Sci., October 1, 2004; 45(10): 3546 - 3554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, and C. G. Crandall Muscle sympathetic nerve activity during lower body negative pressure is accentuated in heat-stressed humans J Appl Physiol, June 1, 2004; 96(6): 2103 - 2108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ichinose, M. Saito, H. Wada, A. Kitano, N. Kondo, and T. Nishiyasu Modulation of arterial baroreflex control of muscle sympathetic nerve activity by muscle metaboreflex in humans Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H701 - H707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, R. Zhang, T. E. Wilson, S. Witkowski, C. G. Crandall, and B. D. Levine Nitric oxide synthase inhibition does not affect regulation of muscle sympathetic nerve activity during head-up tilt Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H2105 - H2110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, and C. G. Crandall Phenylephrine-induced elevations in arterial blood pressure are attenuated in heat-stressed humans Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1221 - R1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, and C. G. Crandall Baroreflex modulation of sympathetic nerve activity to muscle in heat-stressed humans Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R252 - R258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, T. E. Wilson, and C. G. Crandall Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1717 - H1723. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
