Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 91: 1387-1395, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, Y.-Y.
Right arrow Articles by Wong-Riley, M. T. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, Y.-Y.
Right arrow Articles by Wong-Riley, M. T. T.
Vol. 91, Issue 3, 1387-1395, September 2001

Distribution and colocalization of neurotransmitters and receptors in the pre-Bötzinger complex of rats

Ying-Ying Liu1,2, Gong Ju2, and Margaret T. T. Wong-Riley1

1 Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226; and 2 Institute of Neurosciences, Fourth Military Medical University, Xi'an 710032, China

The pre-Bötzinger complex (PBC), thought to be the center of respiratory rhythm generation, is a cell column ventrolateral to the nucleus ambiguus. The present study analyzed its cellular and neurochemical composition in adult rats. PBC neurons were mainly oval, fusiform, or multipolar in shape and small to medium in size. Neurokinin-1 receptor, a marker of the PBC, was present in the plasma membrane of mostly medium and small neurons and their associated processes and boutons. Among neurons immunoreactive for different neurotransmitter or receptor candidates, various numbers were colocalized with neurokinin-1 receptor. The highest ratio was with nitric oxide synthase (52.72%), and the lowest was with glycine receptors (31.93%). Glutamic acid decarboxylase- and glycine transporter 2-immunoreactive boutons, as well as GABAA receptor-immunoreactive plasma membrane processes and boutons, were also identified in the PBC. PBC neurons exhibited different levels of cytochrome oxidase activity, indicating their various energy demands. Our results suggest that synaptic interactions within the PBC of adult rats involve a variety of neurotransmitter and receptor types and that nitric oxide may play an important role in addition to glutamate, GABA, glycine, and neurokinin.

neurokinin-1 receptor; cytochrome oxidase; glutamate; GABA; nitric oxide synthase


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. Pagliardini, J. Ren, and J. J. Greer
Ontogeny of the Pre-Botzinger Complex in Perinatal Rats
J. Neurosci., October 22, 2003; 23(29): 9575 - 9584.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A Monnier, G F Alheid, and D R McCrimmon
Defining ventral medullary respiratory compartments with a glutamate receptor agonist in the rat
J. Physiol., May 1, 2003; 548(3): 859 - 874.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. Telgkamp, Y. Q. Cao, A. I. Basbaum, and J.-M. Ramirez
Long-Term Deprivation of Substance P in PPT-A Mutant Mice Alters the Anoxic Response of the Isolated Respiratory Network
J Neurophysiol, July 1, 2002; 88(1): 206 - 213.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Wang, T. P. Germanson, and P. G. Guyenet
Depressor and Tachypneic Responses to Chemical Stimulation of the Ventral Respiratory Group Are Reduced by Ablation of Neurokinin-1 Receptor-Expressing Neurons
J. Neurosci., May 1, 2002; 22(9): 3755 - 3764.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. G. Guyenet, C. P. Sevigny, M. C. Weston, and R. L. Stornetta
Neurokinin-1 Receptor-Expressing Cells of the Ventral Respiratory Group Are Functionally Heterogeneous and Predominantly Glutamatergic
J. Neurosci., May 1, 2002; 22(9): 3806 - 3816.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Q. Liu and M. T. T. Wong-Riley
Postnatal expression of neurotransmitters, receptors, and cytochrome oxidase in the rat pre-Botzinger complex
J Appl Physiol, March 1, 2002; 92(3): 923 - 934.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online