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1 Biodynamics Laboratory and Department of Kinesiology, 2 Department of Zoology, and 3 Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706
Effects of genetic selection for
high wheel-running activity (17th generation) and access to running
wheels on skeletal muscle glucose uptake were studied in mice with the
following treatments for 8 wk: 1) access to unlocked wheels;
2) same as 1, but wheels locked 48 h before
glucose uptake measurement; or 3) wheels always locked.
Selected mice ran more than random-bred (nonselected) mice (8-wk
mean ± SE = 8,243 ± 711 vs. 3,719 ± 233 revolutions/day). Body weight was 5-13% lower for selected vs.
nonselected groups. Fat pad/body weight was ~40% lower for selected
vs. nonselected and unlocked vs. locked groups. Insulin-stimulated
glucose uptake and fat pad/body weight were inversely correlated for
isolated soleus (r = 
0.333; P < 0.005) but not extensor digitorum longus (EDL) or epitrochlearis
muscles. Insulin-stimulated glucose uptake was higher in EDL
(P < 0.02) for selected vs. nonselected mice. Glucose
uptake did not differ by wheel group, and amount of running did not
correlate with glucose uptake for any muscle. Wheel running by mice did
not enhance subsequent glucose uptake by isolated muscles.
glucose transport; exercise; artificial selection; insulin sensitivity
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