Journal of Applied Physiology AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 91: 1035-1040, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (43)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Milanese, M.
Right arrow Articles by Brusasco, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Milanese, M.
Right arrow Articles by Brusasco, V.
Vol. 91, Issue 3, 1035-1040, September 2001

On the functional consequences of bronchial basement membrane thickening

Manlio Milanese, Emanuele Crimi, Antonio Scordamaglia, Annamaria Riccio, Riccardo Pellegrino, G. Walter Canonica, and Vito Brusasco

Dipartimenti di Scienze Motorie e Riabilitative e di Medicina Interna, Università di Genova, 16132 Genova; and Fisiopatologia Respiratoria, Azienda Ospedaliera S. Croce e Carle, 12100 Cuneo, Italy

Reticular basement membrane (RBM) thickness and airway responses to inhaled methacholine (MCh) were studied in perennial allergic asthma (n = 11), perennial allergic rhinitis (n = 8), seasonal allergic rhinitis (n = 5), and chronic obstructive pulmonary disease (COPD, n = 9). RBM was significantly thicker in asthma (10.1 ± 3.7 µm) and perennial rhinitis (11.2 ± 4.2 µm) than in seasonal rhinitis (4.7 ± 0.7 µm) and COPD (5.2 ± 0.7 µm). The dose (geometric mean) of MCh causing a 20% decrease of 1-s forced expiratory volume (FEV1) was significantly higher in perennial rhinitis (1,073 µg) than in asthma (106 µg). In COPD, the slope of the linear regression of all values of forced vital capacity plotted against FEV1 during the challenge was higher, and the intercept less, than in other groups, suggesting enhanced airway closure. In asthma, RBM thickness was positively correlated (r = 0.77) with the dose (geometric mean) of MCh causing a 20% decrease of FEV1 and negatively correlated (r = -0.73) with the forced vital capacity vs. FEV1 slope. We conclude that 1) RBM thickening is not unique to bronchial asthma, and 2) when present, it may protect against airway narrowing and air trapping. These findings support the opinion that RBM thickening represents an additional load on airway smooth muscle.

airway responsiveness; remodeling; asthma; chronic obstructive pulmonary disease; rhinitis


This article has been cited by other articles:


Home page
 Ther Adv Respir DisHome page
M. Baroffio, G. Barisione, E. Crimi, and V. Brusasco
Noninflammatory mechanisms of airway hyper-responsiveness in bronchial asthma: an overview
Therapeutic Advances in Respiratory Disease, August 1, 2009; 3(4): 163 - 174.
[Abstract] [PDF]

Home page
 Eur Respir JHome page
G. Barisione, E. Crimi, S. Bartolini, R. Saporiti, F. Copello, R. Pellegrino, and V. Brusasco
How to interpret reduced forced expiratory volume in 1 s (FEV1)/vital capacity ratio with normal FEV1
Eur. Respir. J., June 1, 2009; 33(6): 1396 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
C. Bergeron, W. Al-Ramli, and Q. Hamid
Remodeling in Asthma
Proceedings of the ATS, May 1, 2009; 6(3): 301 - 305.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. G. Chapman, N. Berend, G. G. King, and C. M. Salome
Increased airway closure is a determinant of airway hyperresponsiveness
Eur. Respir. J., December 1, 2008; 32(6): 1563 - 1569.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
T. N Hilliard, N. Regamey, J. K Shute, A. G Nicholson, E. W F W Alton, A. Bush, and J. C Davies
Airway remodelling in children with cystic fibrosis
Thorax, December 1, 2007; 62(12): 1074 - 1080.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. L. James and S. Wenzel
Clinical relevance of airway remodelling in airway diseases
Eur. Respir. J., July 1, 2007; 30(1): 134 - 155.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. S. An, T. R. Bai, J. H. T. Bates, J. L. Black, R. H. Brown, V. Brusasco, P. Chitano, L. Deng, M. Dowell, D. H. Eidelman, et al.
Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
Eur. Respir. J., May 1, 2007; 29(5): 834 - 860.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
D. M. Hyde, L. A. Miller, E. S. Schelegle, M. V. Fanucchi, L. S. Van Winkle, N. K. Tyler, M. V. Avdalovic, M. J. Evans, R. Kajekar, A. R. Buckpitt, et al.
Asthma: a comparison of animal models using stereological methods
Eur. Respir. Rev., December 1, 2006; 15(101): 122 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. S. An, B. Fabry, X. Trepat, N. Wang, and J. J. Fredberg
Do Biophysical Properties of the Airway Smooth Muscle in Culture Predict Airway Hyperresponsiveness?
Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 55 - 64.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Bergeron and L.-P. Boulet
Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation.
Chest, April 1, 2006; 129(4): 1068 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. R. Henderson Jr., G. K. S. Chiang, Y.-t. Tien, and E. Y. Chi
Reversal of Allergen-induced Airway Remodeling by CysLT1 Receptor Blockade
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 718 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. J. Wadsworth, A. M. Freyer, R. L. Corteling, and I. P. Hall
Biosynthesized matrix provides a key role for survival signaling in bronchial epithelial cells
Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L596 - L603.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Niimi, H. Matsumoto, M. Takemura, T. Ueda, K. Chin, and M. Mishima
Relationship of Airway Wall Thickness to Airway Sensitivity and Airway Reactivity in Asthma
Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 983 - 988.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Barbato, G. Turato, S. Baraldo, E. Bazzan, F. Calabrese, M. Tura, R. Zuin, B. Beghe, P. Maestrelli, L. M. Fabbri, et al.
Airway Inflammation in Childhood Asthma
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 798 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. J. Evans, M. V. Fanucchi, G. L. Baker, L. S. Van Winkle, L. M. Pantle, S. J. Nishio, E. S. Schelegle, L. J. Gershwin, L. A. Miller, D. M. Hyde, et al.
Atypical development of the tracheal basement membrane zone of infant rhesus monkeys exposed to ozone and allergen
Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L931 - L939.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Brusasco and R. Pellegrino
Invited Review: Complexity of factors modulating airway narrowing in vivo: relevance to assessment of airway hyperresponsiveness
J Appl Physiol, September 1, 2003; 95(3): 1305 - 1313.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. E. McParland, P. T. Macklem, and P. D. Pare
Airway wall remodeling: friend or foe?
J Appl Physiol, July 1, 2003; 95(1): 426 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. A. Olman
Epithelial Cell Modulation of Airway Fibrosis in Asthma
Am. J. Respir. Cell Mol. Biol., February 1, 2003; 28(2): 125 - 128.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. N. R. Payne, A. V. Rogers, E. Adelroth, V. Bandi, K. K. Guntupalli, A. Bush, and P. K. Jeffery
Early Thickening of the Reticular Basement Membrane in Children with Difficult Asthma
Am. J. Respir. Crit. Care Med., January 1, 2003; 167(1): 78 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. M. Waters, P. H. S. Sporn, M. Liu, and J. J. Fredberg
Cellular biomechanics in the lung
Am J Physiol Lung Cell Mol Physiol, September 1, 2002; 283(3): L503 - L509.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. Palmans, R.A. Pauwels, and J.C. Kips
Repeated allergen exposure changes collagen composition in airways of sensitised Brown Norway rats
Eur. Respir. J., August 1, 2002; 20(2): 280 - 285.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Palmans, N. J. Vanacker, R. A. Pauwels, and J. C. Kips
Effect of Age on Allergen-induced Structural Airway Changes in Brown Norway Rats
Am. J. Respir. Crit. Care Med., May 1, 2002; 165(9): 1280 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Latourelle, B. Fabry, and J. J. Fredberg
Dynamic equilibration of airway smooth muscle contraction during physiological loading
J Appl Physiol, February 1, 2002; 92(2): 771 - 779.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Crimi, M. Milanese, S. Oddera, C. Mereu, G. A. Rossi, A. Riccio, G. W. Canonica, and V. Brusasco
Inflammatory and mechanical factors of allergen-induced bronchoconstriction in mild asthma and rhinitis
J Appl Physiol, September 1, 2001; 91(3): 1029 - 1034.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online