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J Appl Physiol 91: 771-776, 2001;
8750-7587/01 $5.00
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Vol. 91, Issue 2, 771-776, August 2001

TGF-beta 1 and prepro-ANP mRNAs are differentially regulated in exercise-induced cardiac hypertrophy

Angelino Calderone1, René J. L. Murphy2, Julie Lavoie3, Federico Colombo1, and Louise Béliveau3

1 Centre de Recherche de l'Institut de Cardiologie de Montréal and Département de Physiologie, and 3 Département de Kinésiologie, Université de Montréal, Montreal, Quebec, Canada H1T 1C8; and 2 School of Recreation Management and Kinesiology, Acadia University, Acadia, Nova Scotia, Canada

The induction of transforming growth factor (TGF)-beta and prepro-atrial natriuretic peptide (ANP) mRNAs represent hallmark features of pathological cardiac hypertrophy. The present study examined whether this pattern of mRNA expression was conserved in a physiological model of cardiac hypertrophy. To address this thesis, female Sprague-Dawley rats were individually housed and permitted to run freely. Voluntary exercise for 3 and 6 wk resulted in biventricular hypertrophy and increased cytochrome c oxidase activity in the triceps muscle. In the hypertrophied left ventricle, the steady-state mRNA level of the cardiac fetal gene prepro-ANP and the extracellular matrix proteins preprocollagen-alpha 1 and fibronectin were similar in exercise-trained and sedentary rats. By contrast, an increased expression of TGF-beta 1 mRNA was observed, whereas TGF-beta 3 mRNA level was unchanged in the hypertrophied left ventricle of exercise-trained compared with sedentary rats. These data highlight a heterogeneity in the regulation of TGF-beta isoforms, and the increased expression of ventricular TGF-beta 1 mRNA in physiological cardiac hypertrophy may contribute to myocardial remodeling.

voluntary exercise (training); physiological cardiac hypertrophy; collagen


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