Journal of Applied Physiology
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J Appl Physiol 91: 709-716, 2001;
8750-7587/01 $5.00
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Vol. 91, Issue 2, 709-716, August 2001

Ventilatory long-term facilitation in unanesthetized rats

E. B. Olson Jr.1, C. J. Bohne1, M. R. Dwinell3, A. Podolsky3, E. H. Vidruk1, D. D. Fuller2, F. L. Powell3, and G. S. Mitchel2

1 The John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705-2368; 2 Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706-1102; and 3 Division of Physiology, Department of Medicine, and White Mountain Research Station, University of California, San Diego, La Jolla, California 92093-0623

We tested the hypothesis that unanesthetized rats exhibit ventilatory long-term facilitation (LTF) after intermittent, but not continuous, hypoxia. Minute ventilation (VE) and carbon dioxide production (VCO2) were measured in unanesthetized, unrestrained male Sprague-Dawley rats via barometric plethysmography before, during, and after exposure to continuous or intermittent hypoxia. Hypoxia was either isocapnic [inspired O2 fraction (FIO2) = 0.08-0.09 and inspired CO2 fraction (FICO2) = 0.04] or poikilocapnic (FIO2 = 0.11 and FICO2 = 0.00). Sixty minutes after intermittent hypoxia, VE or VE/VCO2 was significantly greater than baseline in both isocapnic and poikilocapnic conditions. In contrast, 60 min after continuous hypoxia, VE and VE/VCO2 were not significantly different from baseline values. These data demonstrate ventilatory LTF after intermittent hypoxia in unanesthetized rats. Ventilatory LTF appeared similar in its magnitude (after accounting for CO2 feedback), time course, and dependence on intermittent hypoxia to phrenic LTF previously observed in anesthetized, vagotomized, paralyzed rats.

ventilation; plasticity; intermittent hypoxia; hypoxia; respiratory control


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