Journal of Applied Physiology Millar Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 91: 645-653, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (58)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Perhonen, M. A.
Right arrow Articles by Levine, B. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perhonen, M. A.
Right arrow Articles by Levine, B. D.
Vol. 91, Issue 2, 645-653, August 2001

Cardiac atrophy after bed rest and spaceflight

Merja A. Perhonen, Fatima Franco, Lynda D. Lane, Jay C. Buckey, C. Gunnar Blomqvist, Joseph E. Zerwekh, Ronald M. Peshock, Paul T. Weatherall, and Benjamin D. Levine

Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and Department of Internal Medicine and Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75231

Cardiac muscle adapts well to changes in loading conditions. For example, left ventricular (LV) hypertrophy may be induced physiologically (via exercise training) or pathologically (via hypertension or valvular heart disease). If hypertension is treated, LV hypertrophy regresses, suggesting a sensitivity to LV work. However, whether physical inactivity in nonathletic populations causes adaptive changes in LV mass or even frank atrophy is not clear. We exposed previously sedentary men to 6 (n = 5) and 12 (n = 3) wk of horizontal bed rest. LV and right ventricular (RV) mass and end-diastolic volume were measured using cine magnetic resonance imaging (MRI) at 2, 6, and 12 wk of bed rest; five healthy men were also studied before and after at least 6 wk of routine daily activities as controls. In addition, four astronauts were exposed to the complete elimination of hydrostatic gradients during a spaceflight of 10 days. During bed rest, LV mass decreased by 8.0 ± 2.2% (P = 0.005) after 6 wk with an additional atrophy of 7.6 ± 2.3% in the subjects who remained in bed for 12 wk; there was no change in LV mass for the control subjects (153.0 ± 12.2 vs. 153.4 ± 12.1 g, P = 0.81). Mean wall thickness decreased (4 ± 2.5%, P = 0.01) after 6 wk of bed rest associated with the decrease in LV mass, suggesting a physiological remodeling with respect to altered load. LV end-diastolic volume decreased by 14 ± 1.7% (P = 0.002) after 2 wk of bed rest and changed minimally thereafter. After 6 wk of bed rest, RV free wall mass decreased by 10 ± 2.7% (P = 0.06) and RV end-diastolic volume by 16 ± 7.9% (P = 0.06). After spaceflight, LV mass decreased by 12 ± 6.9% (P = 0.07). In conclusion, cardiac atrophy occurs during prolonged (6 wk) horizontal bed rest and may also occur after short-term spaceflight. We suggest that cardiac atrophy is due to a physiological adaptation to reduced myocardial load and work in real or simulated microgravity and demonstrates the plasticity of cardiac muscle under different loading conditions.

magnetic resonance imaging; left ventricular mass; left ventricular end-diastolic volume; right ventricular mass; right ventricular end-diastolic volume


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L.-F. Zhang, J.-H. Cheng, X. Liu, S. Wang, Y. Liu, H.-B. Lu, and J. Ma
Cardiovascular changes of conscious rats after simulated microgravity with and without daily -Gx gravitation
J Appl Physiol, October 1, 2008; 105(4): 1134 - 1145.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. A. Dorfman, B. D. Rosen, M. A. Perhonen, T. Tillery, R. McColl, R. M. Peshock, and B. D. Levine
Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting
J Appl Physiol, April 1, 2008; 104(4): 1037 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. A. Hill and E. N. Olson
Cardiac Plasticity
N. Engl. J. Med., March 27, 2008; 358(13): 1370 - 1380.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Masuki, J. H. Eisenach, W. G. Schrage, C. P. Johnson, N. M. Dietz, B. W. Wilkins, P. Sandroni, P. A. Low, and M. J. Joyner
Reduced stroke volume during exercise in postural tachycardia syndrome
J Appl Physiol, October 1, 2007; 103(4): 1128 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. A. Dorfman, B. D. Levine, T. Tillery, R. M. Peshock, J. L. Hastings, S. M. Schneider, B. R. Macias, G. Biolo, and A. R. Hargens
Cardiac atrophy in women following bed rest
J Appl Physiol, July 1, 2007; 103(1): 8 - 16.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. M. Baevsky, V. M. Baranov, I. I. Funtova, A. Diedrich, A. V. Pashenko, A. G. Chernikova, J. Drescher, J. Jordan, and J. Tank
Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard the International Space Station
J Appl Physiol, July 1, 2007; 103(1): 156 - 161.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Masuki, J. H. Eisenach, C. P. Johnson, N. M. Dietz, L. M. Benrud-Larson, W. G. Schrage, T. B. Curry, P. Sandroni, P. A. Low, and M. J. Joyner
Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety
J Appl Physiol, March 1, 2007; 102(3): 896 - 903.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. J. Mueller, M. J. Sullivan, R. R. Grindstaff, J. T. Cunningham, and E. M. Hasser
Regulation of plasma vasopressin and renin activity in conscious hindlimb-unloaded rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R46 - R52.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F. Iellamo, M. Di Rienzo, D. Lucini, J. M. Legramante, P. Pizzinelli, P. Castiglioni, F. Pigozzi, M. Pagani, and G. Parati
Muscle metaboreflex contribution to cardiovascular regulation during dynamic exercise in microgravity: insights from mission STS-107 of the space shuttle Columbia
J. Physiol., May 1, 2006; 572(3): 829 - 838.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. V. Pancheva, V. S. Panchev, A. V. Suvandjieva, and B. D. Levine
Lower body negative pressure vs. lower body positive pressure to prevent cardiac atrophy after bed rest and spaceflight. What caused the controversy?
J Appl Physiol, March 1, 2006; 100(3): 1090 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. Norsk, M. Damgaard, L. Petersen, M. Gybel, B. Pump, A. Gabrielsen, and N. J. Christensen
Vasorelaxation in Space
Hypertension, January 1, 2006; 47(1): 69 - 73.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. Hayashi, S. Koba, and T. Yoshida
Disuse atrophy increases the muscle mechanoreflex in rats
J Appl Physiol, October 1, 2005; 99(4): 1442 - 1445.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. J. Christensen, M. Heer, K. Ivanova, and P. Norsk
Sympathetic nervous activity decreases during head-down bed rest but not during microgravity
J Appl Physiol, October 1, 2005; 99(4): 1552 - 1557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. J. Mueller, C. M. Foley, and E. M. Hasser
Hindlimb unloading alters nitric oxide and autonomic control of resting arterial pressure in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R140 - R147.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Gisolf, R. V. Immink, J. J. van Lieshout, W. J. Stok, and J. M. Karemaker
Orthostatic blood pressure control before and after spaceflight, determined by time-domain baroreflex method
J Appl Physiol, May 1, 2005; 98(5): 1682 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. H Naylor, L. F Arnolda, J. A Deague, D. Playford, A. Maurogiovanni, G. O'Driscoll, and D. J Green
Reduced ventricular flow propagation velocity in elite athletes is augmented with the resumption of exercise training
J. Physiol., March 15, 2005; 563(3): 957 - 963.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. C. Barbato, Q.-Q. Huang, M. M. Hossain, M. Bond, and J.-P. Jin
Proteolytic N-terminal Truncation of Cardiac Troponin I Enhances Ventricular Diastolic Function
J. Biol. Chem., February 25, 2005; 280(8): 6602 - 6609.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Spaak, S. Montmerle, P. Sundblad, and D. Linnarsson
Long-term bed rest-induced reductions in stroke volume during rest and exercise: cardiac dysfunction vs. volume depletion
J Appl Physiol, February 1, 2005; 98(2): 648 - 654.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. M. Grenon, S. Hurwitz, N. Sheynberg, X. Xiao, B. Judson, C. D. Ramsdell, C. Kim, R. J. Cohen, and G. H. Williams
Sleep restriction does not affect orthostatic tolerance in the simulated microgravity environment
J Appl Physiol, November 1, 2004; 97(5): 1660 - 1666.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Arbab-Zadeh, E. Dijk, A. Prasad, Q. Fu, P. Torres, R. Zhang, J. D. Thomas, D. Palmer, and B. D. Levine
Effect of Aging and Physical Activity on Left Ventricular Compliance
Circulation, September 28, 2004; 110(13): 1799 - 1805.
[Abstract] [Full Text] [PDF]

Home page
 J Clin PharmacolHome page
A. Graebe, E. L. Schuck, P. Lensing, L. Putcha, and H. Derendorf
Physiological, Pharmacokinetic, and Pharmacodynamic Changes in Space
J. Clin. Pharmacol., August 1, 2004; 44(8): 837 - 853.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. M. Grenon, S. Hurwitz, N. Sheynberg, X. Xiao, C. D. Ramsdell, C. L. Mai, C. Kim, R. J. Cohen, and G. H. Williams
Role of individual predisposition in orthostatic intolerance before and after simulated microgravity
J Appl Physiol, May 1, 2004; 96(5): 1714 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X. Xiao, R. Mukkamala, N. Sheynberg, S. M. Grenon, M. D. Ehrman, T. J. Mullen, C. D. Ramsdell, G. H. Williams, and R. J. Cohen
Effects of simulated microgravity on closed-loop cardiovascular regulation and orthostatic intolerance: analysis by means of system identification
J Appl Physiol, February 1, 2004; 96(2): 489 - 497.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Q. Fu, A. Arbab-Zadeh, M. A. Perhonen, R. Zhang, J. H. Zuckerman, and B. D. Levine
Hemodynamics of orthostatic intolerance: implications for gender differences
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H449 - H457.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Adams, V. J. Caiozzo, and K. M. Baldwin
Skeletal muscle unweighting: spaceflight and ground-based models
J Appl Physiol, December 1, 2003; 95(6): 2185 - 2201.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. E. Watenpaugh and B. Levine
Nocturnal lower body positive pressure to counteract microgravity-induced cardiac remodeling/atrophy
J Appl Physiol, May 1, 2002; 92(5): 2222 - 2223.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online