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J Appl Physiol 91: 637-644, 2001;
8750-7587/01 $5.00
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Vol. 91, Issue 2, 637-644, August 2001

Effects of hypergravity and anti-G suit pressure on intraregional ventilation distribution during VC breaths

Per M. Gustafsson1,2, Ola Eiken1, and Mikael Grönkvist1

1 Swedish Defense Research Agency, Aviation Medicine, S-580 13 Linköping and Karolinska Institutet, S-171 77 Stockholm; and 2 Department of Paediatrics, Central Hospital, S-541 85 Skövde, Sweden

The effects of increased gravity in the head-to-foot direction (+Gz) and pressurization of an anti-G suit (AGS) on total and intraregional intra-acinar ventilation inhomogeneity were explored in 10 healthy male subjects. They performed vital capacity (VC) single-breath washin/washouts of SF6 and He in +1, +2, or +3 Gz in a human centrifuge, with an AGS pressurized to 0, 6, or 12 kPa. The phase III slopes for SF6 and He over 25-75% of the expired VC were used as markers of total ventilation inhomogeneity, and the (SF6 - He) slopes were used as indicators of intraregional intra-acinar inhomogeneity. SF6 and He phase III slopes increased proportionally with increasing gravity, but the (SF6 - He) slopes remained unchanged. AGS pressurization did not change SF6 or He slopes significantly but resulted in increased (SF6 - He) slope differences at 12 kPa. In conclusion, hypergravity increases overall but not intraregional intra-acinar inhomogeneity during VC breaths. AGS pressurization provokes increased intraregional intra-acinar ventilation inhomogeneity, presumably reflecting the consequences of basilar pulmonary vessel engorgement in combination with compression of the basilar lung regions.

gravity; He; SF6; single-breath washout; ventilation inhomogeneity; vital capacity


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