Journal of Applied Physiology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 91: 17-25, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peyton, P. J.
Right arrow Articles by Thompson, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peyton, P. J.
Right arrow Articles by Thompson, B.
Vol. 91, Issue 1, 17-25, July 2001

Effect of ventilation-perfusion inhomogeneity and N2O on oxygenation: physiological modeling of gas exchange

Philip J. Peyton1, Gavin J. B. Robinson2, and Bruce Thompson3

Departments of 1 Anaesthesia and 3 Respiratory Medicine, Austin and Repatriation Medical Centre, Heidelberg 3084; and 2 Department of Anaesthesia and Pain Medicine, The Alfred, Prahan 3181, Melbourne, Victoria, Australia

Ventilation-perfusion (VA/Q) inhomogeneity was modeled to measure its effect on arterial oxygenation during maintenance-phase anesthesia involving an inspired mixture of 30% O2 and either N2O or N2. A multialveolar compartment computer model was constructed based on a log normal distribution of VA/Q inhomogeneity. Increasing the log SD of the distribution of blood flow from 0 to 1.75 produced a progressive fall in arterial PO2 (PaO2). The fall was less steep in the presence of N2O than when N2 was present instead. This was due mainly to the concentrating effect of N2O uptake on alveolar PO2 in moderately low VA/Q compartments. The improvement in PaO2 when N2O was present instead of N2 was greatest when the degree of VA/Q inhomogeneity was in the range typically seen in anesthetized patients. Models based on distributions of expired and inspired alveolar ventilation give quantitatively different results for PaO2. In the presence of VA/Q inhomogeneity, second-gas and concentrating effects may have clinically significant effects on arterial oxygenation even at "steady-state" levels of N2O uptake.

alveolar-arterial difference; oxygen uptake


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
J. S. Yem, M. J. Turner, A. B. Baker, I. H. Young, and A. B. H. Crawford
A tidally breathing model of ventilation, perfusion and volume in normal and diseased lungs
Br. J. Anaesth., November 1, 2006; 97(5): 718 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. F. A. Hendrickx, R. Carette, H. J. M. Lemmens, and A. M. De Wolf
Large volume N2O uptake alone does not explain the second gas effect of N2O on sevoflurane during constant inspired ventilation
Br. J. Anaesth., March 1, 2006; 96(3): 391 - 395.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
P. Peyton, R. M. Carette, J. F. A. Hendrickx, A. M. De Wolf, W. Hess, J. Kannmacher, and J. Kruse
Contamination of anaesthetic gases with nitric oxide and its influence on oxygenation
Br. J. Anaesth., May 1, 2005; 94(5): 687 - 688.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
C. E. W. Hahn and A. D. Farmery
Gas exchange modelling: no more gills, please
Br. J. Anaesth., July 1, 2003; 91(1): 2 - 15.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
L. J. Goldman
Anesthetic Uptake of Sevoflurane and Nitrous Oxide During an Inhaled Induction in Children
Anesth. Analg., February 1, 2003; 96(2): 400 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. P. Whiteley, D. J. Gavaghan, and C. E. W. Hahn
Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2
Br. J. Anaesth., June 1, 2002; 88(6): 771 - 778.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. J. Peyton, G. J. B. Robinson, and B. Thompson
Ventilation-perfusion inhomogeneity increases gas uptake: theoretical modeling of gas exchange
J Appl Physiol, July 1, 2001; 91(1): 3 - 9.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. J. Peyton, G. J. B. Robinson, and B. Thompson
Ventilation-perfusion inhomogeneity increases gas uptake in anesthesia: computer modeling of gas exchange
J Appl Physiol, July 1, 2001; 91(1): 10 - 16.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online