Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol 90: 2197-2202, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 6, 2197-2202, June 2001

Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method

Eric Laffon1, François Laurent2,4, Virginie Bernard3, Laurent De Boucaud2, Dominique Ducassou1, and Roger Marthan4

1 Service de Médecine Nucléaire, 2 Service de Radiologie, and 3 Service de Cardiologie, Hôpital du Haut-Lévêque, 33604 Pessac; and 4 Laboratoire de Physiologie Cellulaire Respiratoire, INSERM EMI 9937-Université Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France

We describe a magnetic resonance (MR) imaging method that emphasizes pressure wave velocity to noninvasively assess pulmonary arterial hypertension. Both the blood flow and the corresponding vessel cross-sectional area (CSA) were measured by MR phase mapping in the main pulmonary artery (MPA) in 15 patients. MPA pressures were also measured, in the same patients, by right-side heart catheterization. Two significant relationships were established: 1) between the pressure wave velocity in the MPA and the mean pressure in the MPA (Ppa) writing pressure wave velocity = 9.25 Ppa - 202.51 (r = 0.82) and 2) between the ratio of pressure wave velocity to the systolic blood velocity peak in the MPA (R) and the mean pressure in the MPA writing R = 0.68 Ppa - 4.33 (r = 0.89). Using these relationships, we estimated two pressure values to frame the actual Ppa value in each patient from the present series with a reasonable reliability percentage (87%).

magnetic resonance imaging; pressure wave velocity; pulmonary circulation; pulmonary hemodynamics


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