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1 Department of Social and Preventive Medicine and Kinesiology, and 2 Laval Hospital, Laval University, Ste. Foy, Quebec, Canada G1K 7P4; 3 Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110; 4 Molecular Endocrinology Laboratory, CHUL Research Center, Ste. Foy, Quebec, Canada G1V 4G2; 5 School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis, Minnesota 55455; 6 Department of Kinesiology, Indiana University, Bloomington, Indiana 47405 - 7000; 7 Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77843; and 8 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisana 70803
An autosomal genomewide
search for genes related to body composition and its changes after a
20-wk endurance-exercise training program has been completed in the
HERITAGE Family Study. Phenotypes included body mass index
(BMI), sum of eight skinfold thicknesses, fat mass (FM), fat-free mass,
percent body fat (%Fat), and plasma leptin levels. A maximum of 364 sib-pairs from 99 Caucasian families was studied with the use of 344 markers with single-point and multipoint linkage analyses. Evidence of
significant linkage was observed for changes in fat-free mass with the
S100A and the insulin-like growth factor I genes (P = 0.0001). Suggestive evidence (2.0 
Lod < 3.0; 0.0001 < P 0.001) was also observed for the changes in FM and
%Fat at 1q31 and 18q21-q23, in %Fat with the uncoupling protein 2 and
3 genes, and in BMI at 5q14-q21. At baseline, suggestive evidence was
observed for BMI at 8q23-q24, 10p15, and 14q11; for FM at 14q11; and
for plasma leptin levels with the low-density lipoprotein receptor
gene. This is the first genomic scan on genes involved in
exercise-training-induced changes in body composition that could
provide information on the determinants of weight loss.
genomewide search; linkage; genetic; body mass index; body fat; fat-free mass
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