Journal of Applied Physiology Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 90: 1729-1735, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kinkead, R.
Right arrow Articles by Gulemetova, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kinkead, R.
Right arrow Articles by Gulemetova, R.
Vol. 90, Issue 5, 1729-1735, May 2001

Stress-induced attenuation of the hypercapnic ventilatory response in awake rats

Richard Kinkead, Lydie Dupenloup, Nadine Valois, and Roumiana Gulemetova

Department of Pediatrics, Laval University, Hôpital St-François d'Assise, Unité de Recherche de Périnatalogie, Quebec City, Quebec, Canada G1L 3L5

To test the hypothesis that stress alters the performance of the respiratory control system, we compared the acute (20 min) responses to moderate hypoxia and hypercapnia of rats previously subjected to immobilization stress (90 min/day) with responses of control animals. Ventilatory measurements were performed on awake rats using whole body plethysmography. Under baseline conditions, there were no differences in minute ventilation between stressed and unstressed groups. Rats previously exposed to immobilization stress had a 45% lower ventilatory response to hypercapnia (inspiratory CO2 fraction = 0.05) than controls. In contrast, stress exposure had no statistically significant effect on the ventilatory response to hypoxia (inspiratory O2 fraction = 0.12). Stress-induced attenuation of the hypercapnic response was associated with reduced tidal volume and inspiratory flow increases; the frequency and timing components of the response were not different between groups. We conclude that previous exposure to a stressful condition that does not constitute a direct challenge to respiratory homeostasis can elicit persistent (>= 24 h) functional plasticity in the ventilatory control system.

restraint stress; hypercapnia; control of breathing; plasticity; hypoventilation


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Montandon, A. Bairam, and R. Kinkead
Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic respiratory chemoreflex in adult rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R922 - R934.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. W. Bavis and G. S. Mitchell
Long-term effects of the perinatal environment on respiratory control
J Appl Physiol, April 1, 2008; 104(4): 1220 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Fournier, M. Allard, R. Gulemetova, V. Joseph, and R. Kinkead
Chronic corticosterone elevation and sex-specific augmentation of the hypoxic ventilatory response in awake rats
J. Physiol., November 1, 2007; 584(3): 951 - 962.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S.-E. Genest, R. Gulemetova, S. Laforest, G. Drolet, and R. Kinkead
Neonatal maternal separation induces sex-specific augmentation of the hypercapnic ventilatory response in awake rat
J Appl Physiol, April 1, 2007; 102(4): 1416 - 1421.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Montandon, R. Kinkead, and A. Bairam
Disruption of adenosinergic modulation of ventilation at rest and during hypercapnia by neonatal caffeine in young rats: role of adenosine A1 and A2A receptors
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1621 - R1631.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S.-E. Genest, R. Gulemetova, S. Laforest, G. Drolet, and R. Kinkead
Neonatal maternal separation and sex-specific plasticity of the hypoxic ventilatory response in awake rat
J. Physiol., January 15, 2004; 554(2): 543 - 557.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. S. Mitchell and S. M. Johnson
Plasticity in Respiratory Motor Control: Invited Review: Neuroplasticity in respiratory motor control
J Appl Physiol, January 1, 2003; 94(1): 358 - 374.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online