Journal of Applied Physiology AJP: Endocrinology and Metabolism
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J Appl Physiol 90: 1657-1662, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 5, 1657-1662, May 2001

Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model

Yoko Hoshi1, Norio Kobayashi1,2, and Mamoru Tamura1

1 Biophysics Group, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 - 0812; 2 Department of Pediatrics, Hokkaido University School of Medicine, Sapporo 060 - 8638, Japan

Using a newly developed perfused rat brain model, we examined direct effects of each change in cerebral blood flow (CBF) and oxygen metabolic rate on cerebral hemoglobin oxygenation to interpret near-infrared spectroscopy signals. Changes in CBF and total hemoglobin (tHb) were in parallel, although tHb showed no change when changes in CBF were small (<= 10%). Increasing CBF caused an increase in oxygenated hemoglobin (HbO2) and a decrease in deoxygenated hemoglobin (deoxy-Hb). Decreasing CBF was accompanied by a decrease in HbO2, whereas changes in direction of deoxy-Hb were various. Cerebral blood congestion caused increases in HbO2, deoxy-Hb, and tHb. Administration of pentylenetetrazole without increasing the flow rate caused increases in HbO2 and tHb with a decrease in deoxy-Hb. There were no significant differences in venous oxygen saturation before vs. during seizure. These results suggest that, in activation studies with near-infrared spectroscopy, HbO2 is the most sensitive indicator of changes in CBF, and the direction of changes in deoxy-Hb is determined by the degree of changes in venous blood oxygenation and volume.

cerebral blood flow; cerebral oxygen metabolic rate; oxygenated hemoglobin; deoxygenated hemoglobin; pentylenetetrazole


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