Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 90: 1657-1662, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (87)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoshi, Y.
Right arrow Articles by Tamura, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoshi, Y.
Right arrow Articles by Tamura, M.
Vol. 90, Issue 5, 1657-1662, May 2001

Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model

Yoko Hoshi1, Norio Kobayashi1,2, and Mamoru Tamura1

1 Biophysics Group, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 - 0812; 2 Department of Pediatrics, Hokkaido University School of Medicine, Sapporo 060 - 8638, Japan

Using a newly developed perfused rat brain model, we examined direct effects of each change in cerebral blood flow (CBF) and oxygen metabolic rate on cerebral hemoglobin oxygenation to interpret near-infrared spectroscopy signals. Changes in CBF and total hemoglobin (tHb) were in parallel, although tHb showed no change when changes in CBF were small (<= 10%). Increasing CBF caused an increase in oxygenated hemoglobin (HbO2) and a decrease in deoxygenated hemoglobin (deoxy-Hb). Decreasing CBF was accompanied by a decrease in HbO2, whereas changes in direction of deoxy-Hb were various. Cerebral blood congestion caused increases in HbO2, deoxy-Hb, and tHb. Administration of pentylenetetrazole without increasing the flow rate caused increases in HbO2 and tHb with a decrease in deoxy-Hb. There were no significant differences in venous oxygen saturation before vs. during seizure. These results suggest that, in activation studies with near-infrared spectroscopy, HbO2 is the most sensitive indicator of changes in CBF, and the direction of changes in deoxy-Hb is determined by the degree of changes in venous blood oxygenation and volume.

cerebral blood flow; cerebral oxygen metabolic rate; oxygenated hemoglobin; deoxygenated hemoglobin; pentylenetetrazole


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Moriguchi and K. Hiraki
Neural origin of cognitive shifting in young children
PNAS, April 7, 2009; 106(14): 6017 - 6021.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
S. Tsujimoto
The Prefrontal Cortex: Functional Neural Development During Early Childhood
Neuroscientist, August 1, 2008; 14(4): 345 - 358.
[Abstract] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
Y Saito, S Aoyama, T Kondo, R Fukumoto, N Konishi, K Nakamura, M Kobayashi, and T Toshima
Frontal cerebral blood flow change associated with infant-directed speech
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2007; 92(2): F113 - F116.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
I. Miyai, H. Yagura, M. Hatakenaka, I. Oda, I. Konishi, and K. Kubota
Longitudinal Optical Imaging Study for Locomotor Recovery After Stroke
Stroke, December 1, 2003; 34(12): 2866 - 2870.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Pott, J. J. Van Lieshout, K. Ide, P. Madsen, and N. H. Secher
Middle cerebral artery blood velocity during intense static exercise is dominated by a Valsalva maneuver
J Appl Physiol, April 1, 2003; 94(4): 1335 - 1344.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. J. Van Lieshout, W. Wieling, J. M. Karemaker, and N. H. Secher
Syncope, cerebral perfusion, and oxygenation
J Appl Physiol, March 1, 2003; 94(3): 833 - 848.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online