| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205
Genetic determinants confer
variation among inbred mouse strains with respect to the magnitude and
pattern of breathing during acute hypoxic challenge. Specifically,
inheritance patterns derived from C3H/HeJ (C3) and C57BL/6J (B6)
parental strains suggest that differences in hypoxic ventilatory
response (HVR) are controlled by as few as two genes. The present study
demonstrates that at least one genetic determinant is located on mouse
chromosome 9. This genotype-phenotype association was established by
phenotyping 52 B6C3F2 (F2) offspring for HVR
characteristics. A genome-wide screen was performed using
microsatellite DNA markers (n = 176) polymorphic
between C3 and B6 mice. By computing log-likelihood values (LOD
scores), linkage analysis compared marker genotypes with minute
ventilation (
E), tidal volume (VT), and
mean inspiratory flow (VT/TI, where
TI is inspiratory time) during acute hypoxic challenge
(inspired O2 fraction = 0.10, inspired CO2
fraction = 0.03 in N2). A putative quantitative trait
locus (QTL) positioned in the vicinity of D9Mit207 was
significantly associated with hypoxic E (LOD = 4.5), VT (LOD = 4.0), and
VT/TI (LOD = 5.1). For each of the three
HVR characteristics, the putative QTL explained more than 30% of the
phenotypic variation among F2 offspring. In conclusion,
this genetic model of differential HVR characteristics demonstrates
that a locus ~33 centimorgans from the centromere on mouse chromosome
9 confers a substantial proportion of the variance in
E, VT, and VT/TI
during acute hypoxic challenge.
C3H/HeJ; C57BL/6J; hypoxic hypoventilation; control of breathing; linkage analysis
This article has been cited by other articles:
|
|
 |
|
  V. Y. Polotsky and C. P. O'Donnell Genomics of Sleep-disordered Breathing Proceedings of the ATS, January 1, 2007; 4(1): 121 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Dwinell, H. V. Forster, J. Petersen, A. Rider, M. P. Kunert, A. W. Cowley Jr., and H. J. Jacob Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains J Appl Physiol, May 1, 2005; 98(5): 1630 - 1638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Reinhard, B. Meyer, H. Fuchs, T. Stoeger, G. Eder, F. Ruschendorf, J. Heyder, P. Nurnberg, M. H. de Angelis, and H. Schulz Genomewide Linkage Analysis Identifies Novel Genetic Loci for Lung Function in Mice Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 880 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gonsenhauser, C. G. Wilson, F. Han, K. P. Strohl, and T. E. Dick Strain differences in murine ventilatory behavior persist after urethane anesthesia J Appl Physiol, September 1, 2004; 97(3): 888 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley and K. W. Broman Interactions in hypoxic and hypercapnic breathing are genetically linked to mouse chromosomes 1 and 5 J Appl Physiol, July 1, 2004; 97(1): 77 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cohen, Z.-Y. Han, R. Grailhe, J. Gallego, C. Gaultier, J.-P. Changeux, and H. Lagercrantz beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure PNAS, October 1, 2002; 99(20): 13272 - 13277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Hodges, H. V. Forster, P. E. Papanek, M. R. Dwinell, and G. E. Hogan Ventilatory phenotypes among four strains of adult rats J Appl Physiol, September 1, 2002; 93(3): 974 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Blitz and J.-M. Ramirez Long-Term Modulation of Respiratory Network Activity Following Anoxia In Vitro J Neurophysiol, June 1, 2002; 87(6): 2964 - 2971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley, M. A. Haxhiu, and E. B. Gauda Differential CO2-induced c-fos gene expression in the nucleus tractus solitarii of inbred mouse strains J Appl Physiol, March 1, 2002; 92(3): 1277 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley, R. Irizarry, S. Flanders, and R. Rabold Functional Genomics of Sleep and Circadian Rhythm: Selected Contribution: Circadian rhythm variation in activity, body temperature, and heart rate between C3H/HeJ and C57BL/6J inbred strains J Appl Physiol, February 1, 2002; 92(2): 870 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Han, S. Subramanian, T. E. Dick, I. A. Dreshaj, and K. P. Strohl Ventilatory behavior after hypoxia in C57BL/6J and A/J mice J Appl Physiol, November 1, 2001; 91(5): 1962 - 1970. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
