Journal of Applied Physiology
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J Appl Physiol 90: 1607-1614, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 4, 1607-1614, April 2001

HIGHLIGHTED TOPICS
Physiological and Genomic Consequences of Intermittent Hypoxia
Selected Contribution: Chemoreflex responses to CO2 before and after an 8-h exposure to hypoxia in humans

Marzieh Fatemian and Peter A. Robbins

University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom

The ventilatory sensitivity to CO2, in hyperoxia, is increased after an 8-h exposure to hypoxia. The purpose of the present study was to determine whether this increase arises through an increase in peripheral or central chemosensitivity. Ten healthy volunteers each underwent 8-h exposures to 1) isocapnic hypoxia, with end-tidal PO2 (PETO2) = 55 Torr and end-tidal PCO2 (PETCO2) = eucapnia; 2) poikilocapnic hypoxia, with PETO2 = 55 Torr and PETCO2 = uncontrolled; and 3) air-breathing control. The ventilatory response to CO2 was measured before and after each exposure with the use of a multifrequency binary sequence with two levels of PETCO2: 1.5 and 10 Torr above the normal resting value. PETO2 was held at 250 Torr. The peripheral (Gp) and the central (Gc) sensitivities were calculated by fitting the ventilatory data to a two-compartment model. There were increases in combined Gp + Gc (26%, P < 0.05), Gp (33%, P < 0.01), and Gc (23%, P = not significant) after exposure to hypoxia. There were no significant differences between isocapnic and poikilocapnic hypoxia. We conclude that sustained hypoxia induces a significant increase in chemosensitivity to CO2 within the peripheral chemoreflex.

peripheral chemoreflex; central chemoreflex; multifrequency binary sequence; altitude; acclimatization; ventilation


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