| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Sport and Exercise Science and 2 Pathology, University of Auckland, Auckland, New Zealand; and 3 Faculty of Physical Education and Health and 4 Department of Surgery, University of Toronto, Toronto, Ontario, Canada M5S 1A1
The effects of increased
functional loading on early cellular regenerative events after
exercise-induced injury in adult skeletal muscle were examined with the
use of in vivo labeling of replicating myofiber nuclei and immunocyto-
and histochemical techniques. Satellite cell proliferation in
the soleus (Sol) of nonexercised rats (0.4 ± 0.2% of fibers) was
unchanged after an initial bout of declined treadmill exercise but was
elevated after two (1.0 ± 0.2%, P 
0.01), but not
four or seven, daily bouts of the same task. Myonuclei produced over
the 7-day period comprised 0.9-1.9% of myonuclei in isolated
fibers of Sol, tibialis anterior, and vastus intermedius of
nonexercised rats. The accretion of new myonuclei was enhanced
(P 0.05) in Sol and vastus intermedius by the initial
exercise followed by normal activity (to 3.1-3.4% of myonuclei)
and more so by continued daily exercise (4.2-5.3%). Observed
coincident with a lower incidence of histological fiber injury and
unchanged fiber diameter and myonuclei per millimeter, the greater new
myonuclear accretion induced by continued muscle loading may contribute
to an enhanced fiber repair and regeneration after
exercise-induced injury.
eccentrically biased exercise; muscle injury; immunocytochemistry; fiber type; bromodeoxyuridine
This article has been cited by other articles:
|
|
 |
|
  D. L. Enns and P. M. Tiidus Estrogen influences satellite cell activation and proliferation following downhill running in rats J Appl Physiol, February 1, 2008; 104(2): 347 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Stratos, R. Rotter, C. Eipel, T. Mittlmeier, and B. Vollmar Granulocyte-colony stimulating factor enhances muscle proliferation and strength following skeletal muscle injury in rats J Appl Physiol, November 1, 2007; 103(5): 1857 - 1863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Scholz Unraveling the basic principles Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1485 - R1487. [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Christiansen and L. K. McLoon The Effect of Resection on Satellite Cell Activity in Rabbit Extraocular Muscle Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 605 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Westerkamp and S. E. Gordon Angiotensin-converting enzyme inhibition attenuates myonuclear addition in overloaded slow-twitch skeletal muscle Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1223 - R1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fluck, C. Dapp, S. Schmutz, E. Wit, and H. Hoppeler Transcriptional profiling of tissue plasticity: role of shifts in gene expression and technical limitations J Appl Physiol, August 1, 2005; 99(2): 397 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Chretien, P. A. Dreyfus, C. Christov, P. Caramelle, J.-L. Lagrange, B. Chazaud, and R. K. Gherardi In Vivo Fusion of Circulating Fluorescent Cells with Dystrophin-Deficient Myofibers Results in Extensive Sarcoplasmic Fluorescence Expression but Limited Dystrophin Sarcolemmal Expression Am. J. Pathol., June 1, 2005; 166(6): 1741 - 1748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kim, E. Barton, N. Muja, S. Yakar, P. Pennisi, and D. LeRoith Intact Insulin and Insulin-Like Growth Factor-I Receptor Signaling Is Required for Growth Hormone Effects on Skeletal Muscle Growth and Function in Vivo Endocrinology, April 1, 2005; 146(4): 1772 - 1779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Dreyfus, F. Chretien, B. Chazaud, Y. Kirova, P. Caramelle, L. Garcia, G. Butler-Browne, and R. K. Gherardi Adult Bone Marrow-Derived Stem Cells in Muscle Connective Tissue and Satellite Cell Niches Am. J. Pathol., March 1, 2004; 164(3): 773 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. J. LANGEN, J. L. J. VAN DER VELDEN, A. M. W. J. SCHOLS, M. C. J. M. KELDERS, E. F. M. WOUTERS, and Y. M. W. JANSSEN-HEININGER Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization FASEB J, February 1, 2004; 18(2): 227 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Rathbone, J. C. Wenke, G. L. Warren, and R. B. Armstrong Importance of satellite cells in the strength recovery after eccentric contraction-induced muscle injury Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1490 - R1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-M. Chen, N. S. Stott, and H. K. Smith Effects of botulinum toxin A injection and exercise on the growth of juvenile rat gastrocnemius muscle J Appl Physiol, October 1, 2002; 93(4): 1437 - 1447. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
