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Departments of 1 Sport and Exercise Science and 2 Pathology, University of Auckland, Auckland, New Zealand; and 3 Faculty of Physical Education and Health and 4 Department of Surgery, University of Toronto, Toronto, Ontario, Canada M5S 1A1
The effects of increased
functional loading on early cellular regenerative events after
exercise-induced injury in adult skeletal muscle were examined with the
use of in vivo labeling of replicating myofiber nuclei and immunocyto-
and histochemical techniques. Satellite cell proliferation in
the soleus (Sol) of nonexercised rats (0.4 ± 0.2% of fibers) was
unchanged after an initial bout of declined treadmill exercise but was
elevated after two (1.0 ± 0.2%, P 
0.01), but not
four or seven, daily bouts of the same task. Myonuclei produced over
the 7-day period comprised 0.9-1.9% of myonuclei in isolated
fibers of Sol, tibialis anterior, and vastus intermedius of
nonexercised rats. The accretion of new myonuclei was enhanced
(P 0.05) in Sol and vastus intermedius by the initial
exercise followed by normal activity (to 3.1-3.4% of myonuclei)
and more so by continued daily exercise (4.2-5.3%). Observed
coincident with a lower incidence of histological fiber injury and
unchanged fiber diameter and myonuclei per millimeter, the greater new
myonuclear accretion induced by continued muscle loading may contribute
to an enhanced fiber repair and regeneration after
exercise-induced injury.
eccentrically biased exercise; muscle injury; immunocytochemistry; fiber type; bromodeoxyuridine
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