Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 90: 1365-1372, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 4, 1365-1372, April 2001

Role of ventilation strategy on perfluorochemical evaporation from the lungs

Mei-Jy Jeng1,2,5, Daniele Trevisanuto3, Carla M. Weis4, William W. Fox4, Aaron B. Cullen5, Marla R. Wolfson5, and Thomas H. Shaffer5

1 Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei; 2 Department of Pediatrics, Children's Medical Center, Veterans General Hospital-Taipei, Taipei 11217, Taiwan, Republic of China; 3 Department of Pediatrics, Padua University, Padua 35158, Italy; 4 Department of Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine; and 5 Departments of Physiology and Pediatrics, Temple University School of Medicine, Philadelphia, Pennsylvania 19140

To study the effect of ventilation strategy on perfluorochemical (PFC) elimination profile (evaporative loss profile; EL), 6 ml/kg of perflubron were instilled into anesthetized normal rabbits. The strategy was to maintain minute ventilation (VE, in ml/min) in three groups: VEL (low-range VE, 208 ± 2), VEM (midrange VE, 250 ± 9), and VEH (high-range VE, 293 ± 1) over 4 h. In three other groups, respiratory rate (RR, breaths/min) was controlled at 20, 30, or 50 with a constant VE and adjusted tidal volume. PFC content in the expired gas was measured, and EL was calculated. There was a significant VE- and time-dependent effect on EL. Initially, percent PFC saturation and loss rate decreased in the VEH > VEM > VEL groups, but by 3 h the lower percent PFC saturation resulted in a loss rate such that VEH < VEM < VEL at 4 h. For the groups at constant VE, there was a significant time effect on EL but no RR effect. In conclusion, EL profile is dependent on VE with little effect of the RR-tidal volume combination. Thus measurement of EL and VE should be considered for the replacement dosing schemes during partial liquid ventilation.

partial liquid ventilation; minute ventilation; elimination; rabbit


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