| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Intercollege Graduate Program in Physiology, 2 General Clinical Research Center at Noll Laboratory, and 3 Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16801; Divisions of 4 Military Performance and 7 Nutrition and Biochemistry, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760; 6 Department of Exercise Science, Skidmore College, Saratoga Springs, New York 12866; and 5 Human Performance Laboratory, Ball State University, Muncie, Iowa 47306
This study evaluated the individual
components of the insulin-like growth factor I (IGF-I) system [i.e.,
total and free IGF-I, insulin-like growth factor binding protein
(IGFBP)-2 and -3, and the acid-labile subunit (ALS)] in 10 young,
healthy men (age: 22 ± 1 yr, height: 177 ± 2 cm, weight:
79 ± 3 kg, body fat: 11 ± 1%) overnight for 13 h
after two conditions: a resting control (Con) and an acute,
heavy-resistance exercise protocol (Ex). The Ex was a
high-volume, multiset exercise protocol that alternated between 10- and
5-repetition maximum sets with 90-s rest periods between sets. The Ex
was performed from 1500 to 1700; blood was obtained immediately
postexercise and sampled throughout the night (every 10 min for the
first hour and every hour thereafter) until 0600 the next morning. For
the first hour, significant differences (P 
0.05) were
only observed for IGFBP-3 (Ex: 3,801 > Con: 3,531 ng/ml). For the
overnight responses, no differences were observed for total or free
IGF-I or IGFBP-3, whereas IGFBP-2 increased (Ex: 561 > Con: 500 ng/ml) and ALS decreased (Ex: 35 < Con: 39 µg/ml) after
exercise. The results from this study suggest that the impact that
resistance exercise exerts on the circulating IGF-I system is not in
the alteration of the amount of IGF-I but rather of the manner in which
IGF-I is partitioned among its family of binding proteins. Thus acute,
heavy-resistance exercise can lead to alterations in the IGF-I system
that can be detected in the systemic circulation.
insulin-like growth factor binding protein-3; insulin-like growth factor binding protein-2; acid-labile subunit; strength training
This article has been cited by other articles:
|
|
 |
|
  K. R. Rarick, M. A. Pikosky, A. Grediagin, T. J. Smith, E. L. Glickman, J. A. Alemany, J. S. Staab, A. J. Young, and B. C. Nindl Energy flux, more so than energy balance, protein intake, or fitness level, influences insulin-like growth factor-I system responses during 7 days of increased physical activity J Appl Physiol, November 1, 2007; 103(5): 1613 - 1621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Nindl, J. A. Alemany, M. D. Kellogg, J. Rood, S. A. Allison, A. J. Young, and S. J. Montain Utility of circulating IGF-I as a biomarker for assessing body composition changes in men during periods of high physical activity superimposed upon energy and sleep restriction J Appl Physiol, July 1, 2007; 103(1): 340 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Petrella, J.-s. Kim, J. M. Cross, D. J. Kosek, and M. M. Bamman Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E937 - E946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Nindl, K. R. Rarick, J. W. Castellani, A. P. Tuckow, J. F. Patton, A. J. Young, and S. J. Montain Altered secretion of growth hormone and luteinizing hormone after 84 h of sustained physical exertion superimposed on caloric and sleep restriction J Appl Physiol, January 1, 2006; 100(1): 120 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Elloumi, N El Elj, M Zaouali, F Maso, E Filaire, Z Tabka, and G Lac IGFBP-3, a sensitive marker of physical training and overtraining Br. J. Sports Med., September 1, 2005; 39(9): 604 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Kraemer, R. J. Durand, E. O. Acevedo, L. G. Johnson, G. R. Kraemer, E. P. Hebert, and V. D. Castracane Rigorous Running Increases Growth Hormone and Insulin-Like Growth Factor-I Without Altering Ghrelin Experimental Biology and Medicine, March 1, 2004; 229(3): 240 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Nindl, J. W. Castellani, A. J. Young, J. F. Patton, M. J. Khosravi, A. Diamandi, and S. J. Montain Differential responses of IGF-I molecular complexes to military operational field training J Appl Physiol, September 1, 2003; 95(3): 1083 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Nindl, C. R. Scoville, K. M. Sheehan, C. D. Leone, and R. P. Mello Gender differences in regional body composition and somatotrophic influences of IGF-I and leptin J Appl Physiol, April 1, 2002; 92(4): 1611 - 1618. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
