| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan; and 2 Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262
Chronic hypoxia causes pulmonary hypertension and right ventricular hypertrophy associated with pulmonary vascular remodeling. Because hypoxia might promote generation of oxidative stress in vivo, we hypothesized that oxidative stress may play a role in the hypoxia-induced cardiopulmonary changes and examined the effect of treatment with the antioxidant N-acetylcysteine (NAC) in rats. NAC reduced hypoxia-induced cardiopulmonary alterations at 3 wk of hypoxia. Lung phosphatidylcholine hydroperoxide (PCOOH) increased at days 1 and 7 of the hypoxic exposure, and NAC attenuated the increase in lung PCOOH. Lung xanthine oxidase (XO) activity was elevated from day 1 through day 21, especially during the initial 3 days of the hypoxic exposure. The XO inhibitor allopurinol significantly inhibited the hypoxia-induced increase in lung PCOOH and pulmonary hypertension, and allopurinol treatment only for the initial 3 days also reduced the hypoxia-induced right ventricular hypertrophy and pulmonary vascular thickening. These results suggest that oxidative stress produced by activated XO in the induction phase of hypoxic exposure contributes to the development of chronic hypoxic pulmonary hypertension.
N-acetylcysteine; phosphatidylcholine hydroperoxide; xanthine oxidase; allopurinol; pulmonary vascular remodeling
This article has been cited by other articles:
|
|
 |
|
  A. Boueiz, M. Damarla, and P. M. Hassoun Xanthine oxidoreductase in respiratory and cardiovascular disorders Am J Physiol Lung Cell Mol Physiol, May 1, 2008; 294(5): L830 - L840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. McNamara, P. Murthy, C. Kantores, L. Teixeira, D. Engelberts, T. van Vliet, B. P. Kavanagh, and R. P. Jankov Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L205 - L213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Jankov, C. Kantores, J. Pan, and J. Belik Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L233 - L245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Snow, V. Kitzis, C. E. Norton, S. N. Torres, K. D. Johnson, N. L. Kanagy, B. R. Walker, and T. C. Resta Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity J Appl Physiol, January 1, 2008; 104(1): 110 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Sanders and J. R. Hoidal The NOX on Pulmonary Hypertension Circ. Res., August 3, 2007; 101(3): 224 - 226. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Demiralay, N. Gursan, and H. Erdem Regulation of nicotine-induced apoptosis of pulmonary artery endothelial cells by treatment of N-acetylcysteine and vitamin E Human and Experimental Toxicology, July 1, 2007; 26(7): 595 - 602. [Abstract] [PDF]
|
|
|
|
|
|
M.-J. Lin, X.-R. Yang, Y.-N. Cao, and J. S. K. Sham Hydrogen peroxide-induced Ca2+ mobilization in pulmonary arterial smooth muscle cells Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1598 - L1608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Baillie, M. G. D. Bates, A. A. R. Thompson, W. S. Waring, R. W. Partridge, M. F. Schnopp, A. Simpson, F. Gulliver-Sloan, S. R. J. Maxwell, and D. J. Webb Endogenous Urate Production Augments Plasma Antioxidant Capacity in Healthy Lowland Subjects Exposed to High Altitude Chest, May 1, 2007; 131(5): 1473 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Kolar, J. Jezkova, P. Balkova, J. Breh, J. Neckar, F. Novak, O. Novakova, H. Tomasova, M. Srbova, B. Ost'adal, et al. Role of oxidative stress in PKC-{delta} upregulation and cardioprotection induced by chronic intermittent hypoxia Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H224 - H230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kantores, P. J. McNamara, L. Teixeira, D. Engelberts, P. Murthy, B. P. Kavanagh, and R. P. Jankov Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L912 - L922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Q. Liu, I. N. Zelko, E. M. Erbynn, J. S. K. Sham, and R. J. Folz Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox) Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L2 - L10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Hampl, J. Bibova, A. Banasova, J. Uhlik, D. Mikova, O. Hnilickova, V. Lachmanova, and J. Herget Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L11 - L20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Couillard and C. Prefaut From muscle disuse to myopathy in COPD: potential contribution of oxidative stress Eur. Respir. J., October 1, 2005; 26(4): 703 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Mellin, M. Isabelle, A. Oudot, C. Vergely-Vandriesse, C. Monteil, B. Di Meglio, J. P. Henry, B. Dautreaux, L. Rochette, C. Thuillez, et al. Transient reduction in myocardial free oxygen radical levels is involved in the improved cardiac function and structure after long-term allopurinol treatment initiated in established chronic heart failure Eur. Heart J., August 1, 2005; 26(15): 1544 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Imamura, B. Luo, J. Limbird, A. Vitello, M. Oka, D. D. Ivy, I. F. McMurtry, C. V. Garat, M. B. Fallon, and E. P. Carter Hypoxic pulmonary hypertension is prevented in rats with common bile duct ligation J Appl Physiol, February 1, 2005; 98(2): 739 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Matsui, T. Shimosawa, K. Itakura, X. Guanqun, K. Ando, and T. Fujita Adrenomedullin Can Protect Against Pulmonary Vascular Remodeling Induced by Hypoxia Circulation, May 11, 2004; 109(18): 2246 - 2251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bowers, C. Cool, R. C. Murphy, R. M. Tuder, M. W. Hopken, S. C. Flores, and N. F. Voelkel Oxidative Stress in Severe Pulmonary Hypertension Am. J. Respir. Crit. Care Med., March 15, 2004; 169(6): 764 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Budhiraja, R. M. Tuder, and P. M. Hassoun Endothelial Dysfunction in Pulmonary Hypertension Circulation, January 20, 2004; 109(2): 159 - 165. [Full Text] [PDF]
|
|
|
|
|
|
R. E. Girgis, D. Li, X. Zhan, J. G. N. Garcia, R. M. Tuder, P. M. Hassoun, and R. A. Johns Attenuation of chronic hypoxic pulmonary hypertension by simvastatin Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H938 - H945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hoshikawa, P. Nana-Sinkam, M. D. Moore, S. Sotto-Santiago, T. Phang, R. L. Keith, K. G. Morris, T. Kondo, R. M. Tuder, N. F. Voelkel, et al. Hypoxia induces different genes in the lungs of rats compared with mice Physiol Genomics, February 6, 2003; 12(3): 209 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Minko, A. Stefanov, and V. Pozharov Lung Edema Clearance: 20 Years of Progress: Selected Contribution: Lung hypoxia: antioxidant and antiapoptotic effects of liposomal alpha -tocopherol J Appl Physiol, October 1, 2002; 93(4): 1550 - 1560. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
