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J Appl Physiol 90: 1258-1266, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 4, 1258-1266, April 2001

Effects of smooth muscle activation on axial mechanical properties of excised canine bronchi

Felix R. Shardonofsky1, Todd M. Officer2, Aladin M. Boriek2, and Joseph R. Rodarte2

Departments of 1 Pediatrics and 2 Medicine, Baylor College of Medicine, Houston, Texas 77030

This study tested the hypothesis that airway smooth muscle (ASM) activation produces an airway active axial force (AAAF). Bronchi (n = 10) immersed in a tissue bath containing 95% O2-5% CO2-equilibrated Krebs solution were subjected to passive axial lengthening and shortening at 0-20 cmH2O of transmural pressure. ASM was relaxed with isoproterenol and activated with methacholine. Axial tensile (epsilon x), transverse compressive (epsilon y), and shear strains (epsilon xy) were computed from the displacements of four markers placed onto the specimen's surface. The AAAF was estimated by subtracting the control axial force (AF) values at a given epsilon x from those obtained after methacholine. epsilon x-AF relationships were curvilinear, with maximum epsilon x being approached at ~15 g of AF. The epsilon y decreased during bronchial lengthening. Cholinergic stimulation produced 1) a decrease of both epsilon x and epsilon y at a given AF relative to control, indicating ASM shortening, and 2) an AAAF that increased with increasing epsilon x and transmural pressure. A portion of the work of expanding the lungs is required to lengthen the airways; therefore, an AAAF would increase lung elastance and recoil.

elastance; compliance; lung recoil; bronchoconstriction; pulmonary mechanics


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