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J Appl Physiol 90: 839-849, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 3, 839-849, March 2001

Effects of perfluorochemical distribution and elimination dynamics on cardiopulmonary function

Thomas F. Miller1, Bart Milestone2, Robert Stern1,2,3, Thomas H. Shaffer1,4, and Marla R. Wolfson1,4

Departments of 1 Physiology, 4 Pediatrics, and 2 Radiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140; and 3 Veterans Administration Hospital and University of Arizona, Tucson, Arizona 85721

Based on a physicochemical property profile, we tested the hypothesis that different perfluorochemical (PFC) liquids may have distinct effects on intrapulmonary PFC distribution, lung function, and PFC elimination kinetics during partial liquid ventilation (PLV). Young rabbits were studied in five groups [healthy, PLV with perflubron (PFB) or with perfluorodecalin (DEC); saline lavage injury and conventional mechanical ventilation (CMV); saline lavage injury PLV with PFB or with DEC]. Arterial blood chemistry, respiratory compliance (Cr), quantitative computed tomography of PFC distribution, and PFC loss rate were assessed for 4 h. Initial distribution of PFB was more homogenous than that of DEC; over time, PFB redistributed to dependent regions whereas DEC distribution was relatively constant. PFC loss rate decreased over time in all groups, was higher with DEC than PFB, and was lower with injury. In healthy animals, arterial PO2 (PaO2) and Cr decreased with either PFC; the decrease was greater and sustained with DEC. Lavaged animals treated with either PFC demonstrated increased PaO2, which was sustained with PFB but deteriorated with DEC. Lavaged animals treated with PFB demonstrated increased Cr, higher PaO2, and lower arterial PCO2 than with CMV or PLV with DEC. The results indicate that 1) initial distribution and subsequent intrapulmonary redistribution of PFC are related to PFC properties; 2) PFC distribution influences PFC elimination, gas exchange, and Cr; and 3) PFC elimination, gas exchange, and Cr are influenced by PFC properties and lung condition.

perfluorocarbon; perflubron; perfluorodecalin; liquid ventilation; kinematic viscosity; vapor pressure; spreading coefficient


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