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J Appl Physiol 90: 821-831, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 3, 821-831, March 2001

Ion transport and regulation of respiratory tract fluid output in dogs

Ben T. Chen1,2,3 and Donovan B. Yeates1,3

Departments of 1 Medicine and 2 Chemical Engineering, University of Illinois at Chicago, and 3 Department of Veterans Affairs, Veterans Affairs Chicago Health Care System, Chicago, Illinois 60612

To investigate the regulation of respiratory tract fluid output (RTFO), we collected the RTFO in an anesthetized canine model after a series of pharmacological interventions (inhibition of Na+-K+-ATPase or Na+-K+-2Cl- cotransporter, 250 µl) and physiological challenges (ionic and/or osmotic perturbation in airway lumen, 250 µl). Whereas 250 µl of aerosolized 0.9% saline caused a transient increase in RTFO, a 250-µl bumetanide-induced increase in RTFO was evident for 18 min and a 250-µl acetylstrophanthidin-induced increase in RTFO persisted for at least 30 min. Dry air ventilation decreased the responses of RTFO to the saline (sham) and acetylstrophanthidin intervention but not the bumetanide intervention. Delivery of 250 mosmol/kgH2O ion-free mannitol (250 µl) caused marked increases in RTFO that were little affected by the administration of acetylstrophanthidin or bumetanide 30 min before these challenges. A 250-µl 550 mosmol/kgH2O ion-free mannitol challenge caused a more marked and prolonged increase in RTFO. Thus aerosol delivery of a low dose of a cardiac glycoside or a near-isosmotic, ion-free, impermeant osmolyte solution may be therapeutically useful by increasing the clearance of secretions from the tracheobronchial airways.

mucus collection; acetylstrophanthidin; bumetanide; airway humidity; mucociliary transport


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