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J Appl Physiol 90: 1158-1164, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 3, 1158-1164, March 2001

HIGHLIGHTED TOPICS
Plasticity in Skeletal, Cardiac, and Smooth Muscle
Invited Review: Plasticity and energetic demands of contraction in skeletal and cardiac muscle

Gary C. Sieck and Michael Regnier

Departments of Anesthesiology and Physiology, Mayo Medical School and Foundation, Rochester, Minnesota 55905; and Department of Bioengineering, University of Washington School of Medicine, Seattle, Washington 98195

Numerous studies have explored the energetic properties of skeletal and cardiac muscle fibers. In this mini-review, we specifically explore the interactions between actin and myosin during cross-bridge cycling and provide a conceptual framework for the chemomechanical transduction that drives muscle fiber energetic demands. Because the myosin heavy chain (MHC) is the site of ATP hydrolysis and actin binding, we focus on the mechanical and energetic properties of different MHC isoforms. Based on the conceptual framework that is provided, we discuss possible sites where muscle remodeling may impact the energetic demands of contraction in skeletal and cardiac muscle.

cross-bridge cycling; actomyosin ATPase; myosin heavy chain; muscle fiber mechanical properties; muscle remodeling


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