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J Appl Physiol 90: 1137-1157, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 3, 1137-1157, March 2001

HIGHLIGHTED TOPICS
Plasticity in Skeletal, Cardiac, and Smooth Muscle
Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle

David A. Hood

Department of Kinesiology and Health Science and Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

Chronic contractile activity produces mitochondrial biogenesis in muscle. This adaptation results in a significant shift in adenine nucleotide metabolism, with attendant improvements in fatigue resistance. The vast majority of mitochondrial proteins are derived from the nuclear genome, necessitating the transcription of genes, the translation of mRNA into protein, the targeting of the protein to a mitochondrial compartment via the import machinery, and the assembly of multisubunit enzyme complexes in the respiratory chain or matrix. Putative signals involved in initiating this pathway of gene expression in response to contractile activity likely arise from combinations of accelerations in ATP turnover or imbalances between mitochondrial ATP synthesis and cellular ATP demand, and Ca2+ fluxes. These rapid events are followed by the activation of exercise-responsive kinases, which phosphorylate proteins such as transcription factors, which subsequently bind to upstream regulatory regions in DNA, to alter transcription rates. Contractile activity increases the mRNA levels of nuclear-encoded proteins such as cytochrome c and mitochondrial transcription factor A (Tfam) and mRNA levels of upstream transcription factors like c-jun and nuclear respiratory factor-1 (NRF-1). mRNA level changes are often most evident during the postexercise recovery period, and they can occur as a result of contractile activity-induced increases in transcription or mRNA stability. Tfam is imported into mitochondria and controls the expression of mitochondrial DNA (mtDNA). mtDNA contributes only 13 protein products to the respiratory chain, but they are vital for electron transport and ATP synthesis. Contractile activity increases Tfam expression and accelerates its import into mitochondria, resulting in increased mtDNA transcription and replication. The result of this coordinated expression of the nuclear and the mitochondrial genomes, along with poorly understood changes in phospholipid synthesis, is an expansion of the muscle mitochondrial reticulum. Further understanding of 1) regulation of mtDNA expression, 2) upstream activators of NRF-1 and other transcription factors, 3) the identity of mRNA stabilizing proteins, and 4) potential of contractile activity-induced changes in apoptotic signals are warranted.

muscle gene expression; signal transduction; adaptation; exercise; mitochondrial DNA


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Home page
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Home page
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Am J Physiol Cell Physiol, July 1, 2007; 293(1): C22 - C29.
[Abstract] [Full Text] [PDF]

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Clinical measures of adiposity and percentage fat loss: which measure most accurately reflects fat loss and what should we aim for?
Arch. Dis. Child., May 1, 2007; 92(5): 399 - 403.
[Abstract] [Full Text] [PDF]

Home page
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Physiol Rev, April 1, 2007; 87(2): 507 - 520.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Energy sensing and regulation of gene expression in skeletal muscle
J Appl Physiol, February 1, 2007; 102(2): 529 - 540.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H. B. Suliman, M. S. Carraway, L. G. Tatro, and C. A. Piantadosi
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J. Cell Sci., January 15, 2007; 120(2): 299 - 308.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
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Effect of nitric oxide synthase inhibition on mitochondrial biogenesis in rat skeletal muscle
J Appl Physiol, January 1, 2007; 102(1): 314 - 320.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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G. B. McClelland, P. M. Craig, K. Dhekney, and S. Dipardo
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J. Physiol., December 1, 2006; 577(2): 739 - 751.
[Abstract] [Full Text] [PDF]

Home page
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Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance
J. Physiol., September 15, 2006; 575(3): 901 - 911.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Diabetes, August 1, 2006; 55(8): 2286 - 2293.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
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J. Exp. Biol., June 15, 2006; 209(12): 2265 - 2275.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E849 - E855.
[Abstract] [Full Text] [PDF]

Home page
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Am J Physiol Cell Physiol, March 1, 2006; 290(3): C844 - C851.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
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J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2006; 61(1): 3 - 13.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Am J Physiol Cell Physiol, October 1, 2005; 289(4): C994 - C1001.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
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J. Physiol., August 15, 2005; 567(1): 349 - 358.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
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Transcriptional profiling of tissue plasticity: role of shifts in gene expression and technical limitations
J Appl Physiol, August 1, 2005; 99(2): 397 - 413.
[Abstract] [Full Text] [PDF]

Home page
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Age-Related Changes of Mitochondrial DNA Content and Mitochondrial Genotypic and Phenotypic Alterations in Rat Hind-Limb Skeletal Muscles
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[Abstract] [Full Text] [PDF]

Home page
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Am J Physiol Endocrinol Metab, April 1, 2005; 288(4): E818 - E825.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
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Muscle remodeling in relation to blood supply: implications for seasonal changes in mitochondrial enzymes
J. Exp. Biol., February 1, 2005; 208(3): 515 - 522.
[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R163 - R172.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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Cardiovasc Res, November 1, 2004; 64(2): 279 - 288.
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Home page
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Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) {alpha} and {delta} and PPAR coactivator 1{alpha} in human skeletal muscle, but not lipid regulatory genes
J. Mol. Endocrinol., October 1, 2004; 33(2): 533 - 544.
[Abstract] [Full Text] [PDF]

Home page
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