Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 90: 1088-1094, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 3, 1088-1094, March 2001

Catecholamines increase lung edema clearance in rats with increased left atrial pressure

Zaher S. Azzam1,2, Fernando J. Saldias3, Alejandro Comellas1, Karen M. Ridge1, David H. Rutschman4, and Jacob I. Sznajder1

1 Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago 60611; 4 Department of Mathematics, Northeastern Illinois University, Chicago, Illinois 60625; 2 Department of Medicine, Technion, Israel Institute of Technology, 31096 Haifa, Israel; and 3 Departamento de Enfermedades Respiratorias, Facultad de Medicina, Universidad Católica de Chile, Santiago, Chile

During hydrostatic pulmonary edema, active Na+ transport and alveolar fluid reabsorption are decreased. Dopamine (DA) and isoproterenol (ISO) have been shown to increase active Na+ transport in rat lungs by upregulating Na+-K+-ATPase in the alveolar epithelium. We studied the effects of DA and ISO in isolated rat lungs with increased left atrial pressure (Pla = 15 cmH2O) compared with control rats with normal Pla (Pla = 0). Alveolar fluid reabsorption decreased from control value of 0.51 ± 0.02 to 0.27 ± 0.02 ml/h when Pla was increased to 15 cmH2O (P < 0.001). DA and ISO increased the alveolar fluid reabsorption back to control levels. Treatment with the D1 antagonist SCH-23390 inhibited the stimulatory effects of DA (0.30 ± 0.02 ml/h), whereas fenoldopam, a specific D1-receptor agonist, increased alveolar fluid reabsorption in rats exposed to Pla of 15 cmH2O (0.47 ± 0.04 ml/h). Propranolol, a beta -adrenergic-receptor antagonist, blocked the stimulatory effects of ISO; however, it did not affect alveolar fluid reabsorption in control or DA-treated rats. Amiloride (a Na+ channel blocker) and ouabain (a Na+-K+-ATPase inhibitor), either alone or together, inhibited the stimulatory effects of DA. Colchicine, which disrupts the cellular microtubular transport of ion-transporting proteins to the plasma membrane, inhibited the stimulatory effects of DA, whereas the isomer beta -lumicolchicine did not block the stimulatory effects of DA. These data suggest that DA and ISO increase alveolar fluid reabsorption in a model of increased Pla by regulating active Na+ transport in rat alveolar epithelium. The effects of DA and ISO are mediated by the activation of dopaminergic D1 receptors and the beta -adrenergic receptors, respectively.

active sodium transport; cytoskeleton


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