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1 Human Performance Laboratory and Departments of Exercise and Sport Science, Biochemistry, and Surgery, East Carolina University, Greenville, North Carolina 27858; 2 Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016; and 3 Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808-4124
The purpose of this study was to compare substrate utilization
during fasting and submaximal exercise in morbidly obese women after
weight loss (WL) with that in weight-matched controls (C). WL were
studied in the weight-stable condition ~24 mo after gastric bypass
surgery. Energy intake (self-reported) and expenditure (2H218O) were also compared. The
respiratory exchange ratio during exercise at the same absolute (15 W)
workload was significantly (P 
0.05) elevated in WL vs. C
(0.90 ± 0.02 vs. 0.83 ± 0.03); this was reflected as lower
fat utilization in WL (29.7 ± 4.8 vs. 53.2 ± 9.7% of energy from fat). Respiratory exchange ratio during exercise at the
same relative (65% of maximal O2 uptake) intensity was
also significantly (P < 0.05) elevated in WL
(0.96 ± 0.01 vs. 0.89 ± 0.02), and fat use was
concomitantly depressed (12.4 ± 3.0 vs. 34.3 ± 9.9% of
energy from fat). Resting substrate utilization, daily energy
expenditure, and self-reported relative macronutrient intake did not
differ between groups. These data suggest that lipid oxidation is
depressed during physical activity in WL. This defect may, at least in
part, contribute to a propensity for the development of morbid obesity.
fat; lipid; obesity
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