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1 Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver V6Z 1Y6; and 2 Departments of Anatomy and Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
The ability of rabbit trachealis to undergo plastic adaptation to chronic shortening or lengthening was assessed by setting the muscle preparations at three lengths for 24 h in relaxed state: a reference length in which applied force was ~1-2% of maximal active force (Po) and lengths considerably shorter and longer than the reference. Passive and active length-tension (L-T) curves for the preparations were then obtained by electrical field stimulation at progressively increasing muscle length. Classically shaped L-T curves were obtained with a distinct optimal length (Lo) at which Po developed; however, both the active and passive L-T curves were shifted, whereas Po remained unchanged. Lo was 72% and 148% that of the reference preparations for the passively shortened and lengthened muscles, respectively. The results suggest that chronic narrowing of the airways could induce a shift in the L-T relationship of smooth muscle, resulting in a maintained potential for maximal force production.
rabbit trachealis; isometric contraction; tension recovery; plasticity
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