Journal of Applied Physiology Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 90: 638-648, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maron, M. B.
Right arrow Articles by West, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maron, M. B.
Right arrow Articles by West, J. B.
Vol. 90, Issue 2, 638-648, February 2001

Effect of high transcapillary pressures on capillary ultrastructure and permeability coefficients in dog lung

Michael B. Maron1, Zhenxing Fu2, Odile Mathieu-Costello2, and John B. West2

1 Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272-0095; and 2 Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623

To determine the correlation between ultrastructural and physiological changes in blood-gas barrier function in lungs transiently exposed to very high vascular pressures, we increased capillary transmural pressure (Ptm) of 6 canine isolated perfused left lower lung lobe preparations (high-pressure group) to 80.3 Torr for 3.8 min and then determined the capillary filtration (Kfc) and osmotic reflection (sigma d) coefficients at a Ptm of 19.1 Torr in the ventilated lung lobes. This was followed by perfusion fixation of the lobes at a Ptm of 20.5 Torr for ultrastructural analysis. These data were compared with those obtained in six lobes in which Ptm was not transiently elevated before Kfc, sigma d, and ultrastructural evaluation. Kfc was higher [0.249 ± 0.042 (SE) vs. 0.054 ± 0.009 g · min-1 · Torr-1 · 100 g-1; P < 0.01] and sigma d was lower (0.52 ± 0.07 vs. 0.85 ± 0.08; P < 0.01) in the high-pressure group. In contrast, although endothelial and epithelial breaks were occasionally observed in some experiments, their incidence was not increased in the high-pressure group. These data suggest that the increased transvascular water and protein flux occurred through pathways of a size not resolvable by electron microscopy after vascular perfusion-fixation at a Ptm of 20.5 Torr.

blood-gas barrier; capillary wall stress; increased permeability edema; capillary filtration coefficient; osmotic reflection coefficient; barotrauma


This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M.-Y. Jian, J. A. King, A.-B. Al-Mehdi, W. Liedtke, and M. I. Townsley
High Vascular Pressure-Induced Lung Injury Requires P450 Epoxygenase-Dependent Activation of TRPV4
Am. J. Respir. Cell Mol. Biol., April 1, 2008; 38(4): 386 - 392.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
U. F.W. Franke, T. Wittwer, M. Lessel, K. Liebing, M. Albert, V. Becker, H. Schubert, and T. Wahlers
Evaluation of isolated lung perfusion as neoadjuvant therapy of lung metastases using a novel in vivo pig model: I. Influence of perfusion pressure and hyperthermia on functional and morphological lung integrity
Eur. J. Cardiothorac. Surg., October 1, 2004; 26(4): 792 - 799.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Duggan, C. L. McCaul, P. J. McNamara, D. Engelberts, C. Ackerley, and B. P. Kavanagh
Atelectasis Causes Vascular Leak and Lethal Right Ventricular Failure in Uninjured Rat Lungs
Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1633 - 1640.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online