Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 90: 538-544, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 2, 538-544, February 2001

Steady-state measurement of NO and CO lung diffusing capacity on moderate exercise in men

Colin Borland1, Bryan Mist2, Mariella Zammit3, and Alain Vuylsteke3

1 Department of Medicine, Hinchingbrooke Hospital, Huntingdon, Cambridgeshire PE18 8NT; 2 Department of Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE; and 3 Anaesthetic Department, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, United Kingdom

Using a rapidly responding nitric oxide (NO) analyzer, we measured the steady-state NO diffusing capacity (DLNO) from end-tidal NO. The diffusing capacity of the alveolar capillary membrane and pulmonary capillary blood volume were calculated from the steady-state diffusing capacity for CO (measured simultaneously) and the specific transfer conductance of blood per milliliter for NO and for CO. Nine men were studied bicycling at an average O2 consumption of 1.3 ± 0.2 l/min (mean ± SD). DLNO was 202.7 ± 71.2 ml · min-1 · Torr-1 and steady-state diffusing capacity for CO, calculated from end-tidal (assumed alveolar) CO2, mixed expired CO2, and mixed expired CO, was 46.9 ± 12.8 ml · min-1 · Torr-1. NO dead space = (VT × FENO - VT × FANO)/(FINO - FANO) = 209 ± 88 ml, where VT is tidal volume and FENO, FINO, and FANO are mixed exhaled, inhaled, and alveolar NO concentrations, respectively. We used the Bohr equation to estimate CO2 dead space from mixed exhaled and end-tidal (assumed alveolar) CO2 = 430 ± 136 ml. Predicted anatomic dead space = 199 ± 22 ml. Membrane diffusing capacity was 333 and 166 ml · min-1 · Torr-1 for NO and CO, respectively, and pulmonary capillary blood volume was 140 ml. Inhalation of repeated breaths of NO over 80 s did not alter DLNO at the concentrations used.

alveolar capillary gas diffusion; dead space; membrane diffusing capacity; lung capillary blood volume


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