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Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
We used an
exercise paradigm with repeated bouts of heavy forearm exercise to test
the hypothesis that alterations in local acid-base environment that
remain after the first exercise result in greater blood flow and
O2 delivery at the onset of the second bout of exercise.
Two bouts of handgrip exercise at 75% peak workload were performed for
5 min, separated by 5 min of recovery. We continuously measured blood
flow using Doppler ultrasound and sampled venous blood for
O2 content, PCO2, pH, and lactate
and potassium concentrations, and we calculated muscle O2
uptake (
O2). Forearm blood flow was
elevated before the second exercise compared with the first and
remained higher during the first 30 s of exercise (234 ± 18 vs. 187 ± 4 ml/min, P < 0.05). Flow was not
different at 5 min. Arteriovenous O2 content difference was
lower before the second bout (4.6 ± 0.9 vs. 7.2 ± 0.7 ml
O2/dl) and higher by 30 s of exercise
(11.2 ± 0.7 vs. 10.8 ± 0.7 ml O2/dl,
P < 0.05). Muscle O2
was unchanged before the start of exercise but was elevated during the
first 30 s of the transition to the second exercise bout
(26.0 ± 2.1 vs. 20.0 ± 0.9 ml/min, P < 0.05). Changes in venous blood PCO2, pH, and
lactate concentration were consistent with reduced reliance on
anaerobic glycolysis at the onset of the second exercise bout. These
data show that limitations of muscle blood flow can restrict the
adaptation of oxidative metabolism at the onset of heavy muscular exertion.
blood flow; metabolism; blood acid-base; O2 transport; Doppler ultrasound
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