Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 90: 345-357, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (102)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baldwin, K. M.
Right arrow Articles by Haddad, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baldwin, K. M.
Right arrow Articles by Haddad, F.
Vol. 90, Issue 1, 345-357, January 2001

HIGHLIGHTED TOPICS
Plasticity in Skeletal, Cardiac, and Smooth Muscle
Invited Review: Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle

Kenneth M. Baldwin and Fadia Haddad

Department of Physiology and Biophysics, University of California, Irvine, California 92697

The goal of this mini-review is to summarize findings concerning the role that different models of muscular activity and inactivity play in altering gene expression of the myosin heavy chain (MHC) family of motor proteins in mammalian cardiac and skeletal muscle. This was done in the context of examining parallel findings concerning the role that thyroid hormone (T3, 3,5,3'-triiodothyronine) plays in MHC expression. Findings show that both cardiac and skeletal muscles of experimental animals are initially undifferentiated at birth and then undergo a marked level of growth and differentiation in attaining the adult MHC phenotype in a T3/activity level-dependent fashion. Cardiac MHC expression in small mammals is highly sensitive to thyroid deficiency, diabetes, energy deprivation, and hypertension; each of these interventions induces upregulation of the beta -MHC isoform, which functions to economize circulatory function in the face of altered energy demand. In skeletal muscle, hyperthyroidism, as well as interventions that unload or reduce the weight-bearing activity of the muscle, causes slow to fast MHC conversions. Fast to slow conversions, however, are seen under hypothyroidism or when the muscles either become chronically overloaded or subjected to intermittent loading as occurs during resistance training and endurance exercise. The regulation of MHC gene expression by T3 or mechanical stimuli appears to be strongly regulated by transcriptional events, based on recent findings on transgenic models and animals transfected with promoter-reporter constructs. However, the mechanisms by which T3 and mechanical stimuli exert their control on transcriptional processes appear to be different. Additional findings show that individual skeletal muscle fibers have the genetic machinery to express simultaneously all of the adult MHCs, e.g., slow type I and fast IIa, IIx, and IIb, in unique combinations under certain experimental conditions. This degree of heterogeneity among the individual fibers would ensure a large functional diversity in performing complex movement patterns. Future studies must now focus on 1) the signaling pathways and the underlying mechanisms governing the transcriptional/translational machinery that control this marked degree of plasticity and 2) the morphological organization and functional implications of the muscle fiber's capacity to express such a diversity of motor proteins.

muscle plasticity; neonatal development; functional overload; spaceflight; spinal injury; endurance exercise; thyroid state; gene transcription


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Rinaldi, F. Haddad, P. W. Bodell, A. X. Qin, W. Jiang, and K. M. Baldwin
Intergenic bidirectional promoter and cooperative regulation of the IIx and IIb MHC genes in fast skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R208 - R218.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
K. Legerlotz, B. Elliott, B. Guillemin, and H. K. Smith
Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats
Exp Physiol, June 1, 2008; 93(6): 754 - 762.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P. Negredo, J.-L. L. Rivero, B. Gonzalez, A. Ramon-Cueto, and R. Manso
Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantation
J. Physiol., May 15, 2008; 586(10): 2593 - 2610.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
R. R. Roy, D. J. Pierotti, A. Garfinkel, H. Zhong, K. M. Baldwin, and V. R. Edgerton
Persistence of motor unit and muscle fiber types in the presence of inactivity
J. Exp. Biol., April 1, 2008; 211(7): 1041 - 1049.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
K. A. Huey, R. R. Roy, H. Zhong, and C. Lullo
Time-dependent changes in caspase-3 activity and heat shock protein 25 after spinal cord transection in adult rats
Exp Physiol, March 1, 2008; 93(3): 415 - 425.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
L. Mendler, S. Pinter, M. Kiricsi, Z. Baka, and L. Dux
Regeneration of Reinnervated Rat Soleus Muscle Is Accompanied by Fiber Transition Toward a Faster Phenotype
J. Histochem. Cytochem., February 1, 2008; 56(2): 111 - 123.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. Irrcher, D. R. Walkinshaw, T. E. Sheehan, and D. A. Hood
Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo
J Appl Physiol, January 1, 2008; 104(1): 178 - 185.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. Koulmann, L. Bahi, F. Ribera, H. Sanchez, B. Serrurier, R. Chapot, A. Peinnequin, R. Ventura-Clapier, and X. Bigard
Thyroid hormone is required for the phenotype transitions induced by the pharmacological inhibition of calcineurin in adult soleus muscle of rats
Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E69 - E77.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. E. Pandorf, F. Haddad, A. X. Qin, and K. M. Baldwin
IIx myosin heavy chain promoter regulation cannot be characterized in vivo by direct gene transfer
Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1338 - C1346.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
S. Schiaffino, M. Sandri, and M. Murgia
Activity-Dependent Signaling Pathways Controlling Muscle Diversity and Plasticity
Physiology, August 1, 2007; 22(4): 269 - 278.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. L. J. van der Velden, R. C. J. Langen, M. C. J. M. Kelders, J. Willems, E. F. M. Wouters, Y. M. W. Janssen-Heininger, and A. M. W. J. Schols
Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3beta
Am J Physiol Cell Physiol, May 1, 2007; 292(5): C1636 - C1644.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
B. L. Symonds, R. S. James, and C. E. Franklin
Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivating Cyclorana alboguttata (Gunther 1867)
J. Exp. Biol., March 1, 2007; 210(5): 825 - 835.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Z. B. Yu, F. Gao, H. Z. Feng, and J.-P. Jin
Differential regulation of myofilament protein isoforms underlying the contractility changes in skeletal muscle unloading
Am J Physiol Cell Physiol, March 1, 2007; 292(3): C1192 - C1203.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. E. Pandorf, F. Haddad, R. R. Roy, A. X. Qin, V. R. Edgerton, and K. M. Baldwin
Dynamics of Myosin Heavy Chain Gene Regulation in Slow Skeletal Muscle: ROLE OF NATURAL ANTISENSE RNA
J. Biol. Chem., December 15, 2006; 281(50): 38330 - 38342.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Carroll, R. D. Herbert, J. Munn, M. Lee, and S. C. Gandevia
Contralateral effects of unilateral strength training: evidence and possible mechanisms
J Appl Physiol, November 1, 2006; 101(5): 1514 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
H. W. de Jonge, C. W. van der Wiel, K. Eizema, W. A. Weijs, and M. E. Everts
Presence of SERCA and Calcineurin during Fetal Development of Porcine Skeletal Muscle
J. Histochem. Cytochem., June 1, 2006; 54(6): 641 - 648.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
J.A.M Korfage, J.H. Koolstra, G.E.J. Langenbach, and T.M.G.J. van Eijden
Fiber-type Composition of the Human Jaw Muscles--(Part 1) Origin and Functional Significance of Fiber-type Diversity
J. Dent. Res., September 1, 2005; 84(9): 774 - 783.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Fluck, S. Schmutz, M. Wittwer, H. Hoppeler, and D. Desplanches
Transcriptional reprogramming during reloading of atrophied rat soleus muscle
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R4 - R14.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Toth, D. E. Matthews, R. P. Tracy, and M. J. Previs
Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation
Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E883 - E891.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Wang, Q.-Q. Huang, M. T. Breckenridge, A. Chen, T. O. Crawford, D. H. Morton, and J.-P. Jin
Cellular Fate of Truncated Slow Skeletal Muscle Troponin T Produced by Glu180 Nonsense Mutation in Amish Nemaline Myopathy
J. Biol. Chem., April 8, 2005; 280(14): 13241 - 13249.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Z. A Rana, K. Gundersen, A. Buonanno, and D. Vullhorst
Imaging transcription in vivo: distinct regulatory effects of fast and slow activity patterns on promoter elements from vertebrate troponin I isoform genes
J. Physiol., February 1, 2005; 562(3): 815 - 828.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad, K. M. Baldwin, and P. A. Tesch
Pretranslational markers of contractile protein expression in human skeletal muscle: effect of limb unloading plus resistance exercise
J Appl Physiol, January 1, 2005; 98(1): 46 - 52.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. C. Rourke, A. Qin, F. Haddad, K. M. Baldwin, and V. J. Caiozzo
Cloning and sequencing of myosin heavy chain isoform cDNAs in golden-mantled ground squirrels: effects of hibernation on mRNA expression
J Appl Physiol, November 1, 2004; 97(5): 1985 - 1991.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. A. Shanely, D. Van Gammeren, K. C. DeRuisseau, A. M. Zergeroglu, M. J. McKenzie, K. E. Yarasheski, and S. K. Powers
Mechanical Ventilation Depresses Protein Synthesis in the Rat Diaphragm
Am. J. Respir. Crit. Care Med., November 1, 2004; 170(9): 994 - 999.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. L. Radzyukevich and J. A. Heiny
Regulation of dihydropyridine receptor gene expression in mouse skeletal muscles by stretch and disuse
Am J Physiol Cell Physiol, November 1, 2004; 287(5): C1445 - C1452.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. A. Spier, M. D. Delp, C. J. Meininger, A. J. Donato, M. W. Ramsey, and J. M. Muller-Delp
Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles
J. Physiol., May 1, 2004; 556(3): 947 - 958.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. S. Richardson, B. T. Leek, T. P. Gavin, L. J. Haseler, S. R. D. Mudaliar, R. Henry, O. Mathieu-Costello, and P. D. Wagner
Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak VO2 with Small Muscle Mass Exercise
Am. J. Respir. Crit. Care Med., January 1, 2004; 169(1): 89 - 96.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad, R. R. Roy, H. Zhong, V. R. Edgerton, and K. M. Baldwin
Atrophy responses to muscle inactivity. I. Cellular markers of protein deficits
J Appl Physiol, August 1, 2003; 95(2): 781 - 790.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-P. Jin, M. A. Brotto, M. M. Hossain, Q.-Q. Huang, L. S. Brotto, T. M. Nosek, D. H. Morton, and T. O. Crawford
Truncation by Glu180 Nonsense Mutation Results in Complete Loss of Slow Skeletal Muscle Troponin T in a Lethal Nemaline Myopathy
J. Biol. Chem., July 3, 2003; 278(28): 26159 - 26165.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. McGuire, M. MacDermott, and A. Bradford
Effects of Chronic Intermittent Asphyxia on Rat Diaphragm and Limb Muscle Contractility
Chest, March 1, 2003; 123(3): 875 - 881.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Truijens, H. M. Toussaint, J. Dow, and B. D. Levine
Effect of high-intensity hypoxic training on sea-level swimming performances
J Appl Physiol, February 1, 2003; 94(2): 733 - 743.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
B. W. C. Rosser and E. Bandman
Heterogeneity of protein expression within muscle fibers
J Anim Sci, February 1, 2003; 81(14_suppl_2): E94 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. W. Tsika, J. McCarthy, N. Karasseva, Y. Ou, and G. L. Tsika
Divergence in species and regulatory role of beta -myosin heavy chain proximal promoter muscle-CAT elements
Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1761 - C1775.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. M. Diffee, K. Kalfas, S. Al-Majid, and D. O. McCarthy
Altered expression of skeletal muscle myosin isoforms in cancer cachexia
Am J Physiol Cell Physiol, November 1, 2002; 283(5): C1376 - C1382.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
S. Machida, H. Tsujimoto, H. Suzuki, N. Kasuga, K. Kobayashi, and M. Narusawa
Age-Related Differences in the Effect of Running Training on Cardiac Myosin Isozyme Composition in Rats
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2002; 57(9): B339 - 343.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. C. Harrison, M. L. Bell, D. L. Allen, W. C. Byrnes, and L. A. Leinwand
Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice
J Appl Physiol, January 1, 2002; 92(1): 313 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. O. Mitchell and G. K. Pavlath
A muscle precursor cell-dependent pathway contributes to muscle growth after atrophy
Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1706 - C1715.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online