|
|
||||||||
1 Radiology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto 94304; and Departments of 3 Radiology and 2 Mechanical Engineering (Biomechanical Engineering Division), Stanford University, Stanford, California 94305
The purpose of this study was to determine whether [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) can be used to evaluate muscle force production, create anatomic images of muscle activity, and resolve the distribution of metabolic activity within exercising skeletal muscle. Seventeen subjects performed either elbow flexion, elbow extension, or ankle plantar flexion after intravenous injection of FDG. PET imaging was performed subsequently, and FDG uptake was measured in skeletal muscle for each task. A fivefold increase in resistance during elbow flexion increased FDG uptake in the biceps brachii by a factor of 4.9. Differences in relative FDG uptake were demonstrated as exercise tasks and loads were varied, permitting differentiation of active muscles. The intramuscular distribution of FDG within exercising biceps brachii varied along the transverse and longitudinal axes of the muscle; coefficients of variation along these axes were 0.39 and 0.23, respectively. These findings suggest FDG PET is capable of characterizing task-specific muscle activity and measuring intramuscular variations of glucose metabolism within exercising skeletal muscle.
positron emission tomography; fluorodeoxyglucose; intramuscular; tomographic; in vivo
This article has been cited by other articles:
![]() |
Y. Gondoh, M. Tashiro, M. Itoh, M. M. Masud, H. Sensui, S. Watanuki, K. Ishii, H. Takekura, R. Nagatomi, and T. Fujimoto Evaluation of individual skeletal muscle activity by glucose uptake during pedaling exercise at different workloads using positron emission tomography J Appl Physiol, August 1, 2009; 107(2): 599 - 604. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y ARIJI, N FUWA, T KODAIRA, H TACHIBANA, T NAKAMURA, Y SATOH, and E ARIJI False-positive positron emission tomography appearance with 18F-fluorodeoxyglucose after definitive radiotherapy for cancer of the mobile tongue Br. J. Radiol., January 1, 2009; 82(973): e3 - e7. [Abstract] [Full Text] [PDF] |
||||
![]() |
H Shimada, T Suzuki, Y Kimura, T Hirata, M Sugiura, Y Endo, K Yasuhara, K Shimada, K Kikuchi, K Oda, et al. Effects of an automated stride assistance system on walking parameters and muscular glucose metabolism in elderly adults Br. J. Sports Med., November 1, 2008; 42(11): 922 - 929. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. H. Sung, J. Y. Choi, D.-H. Kim, E.-S. Kim, Y.-I. Son, Y.-S. Cho, S. J. Lee, K.-H. Lee, and B.-T. Kim Localization of Dystonic Muscles with 18F-FDG PET/CT in Idiopathic Cervical Dystonia J. Nucl. Med., November 1, 2007; 48(11): 1790 - 1795. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. S. Jackson, T. C. Schlarman, W. L. Hubble, and M. M. Osman Prevalence and Patterns of Physiologic Muscle Uptake Detected with Whole-Body 18F-FDG PET. J. Nucl. Med. Technol., March 1, 2006; 34(1): 29 - 33. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Yamaguchi, H. Rikimaru, K. Yamaguchi, M. Itoh, and M. Watanabe Overall Activity of All Masticatory Muscles during Lateral Excursion Journal of Dental Research, January 1, 2006; 85(1): 69 - 73. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. J. Durham, S. L. Miller, C. W. Yeckel, D. L. Chinkes, K. D. Tipton, B. B. Rasmussen, and R. R. Wolfe Leg glucose and protein metabolism during an acute bout of resistance exercise in humans J Appl Physiol, October 1, 2004; 97(4): 1379 - 1386. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |