Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 90: 287-298, 2001;
8750-7587/01 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nash, M. P.
Right arrow Articles by Paterson, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nash, M. P.
Right arrow Articles by Paterson, D. J.
Vol. 90, Issue 1, 287-298, January 2001

Ventricular activation during sympathetic imbalance and its computational reconstruction

Martyn P. Nash1, Judith M. Thornton1, Claire E. Sears2, Anthony Varghese3, Mark O'Neill1, and David J. Paterson1

1 University Laboratory of Physiology, Oxford OX1 3PT; and 2 Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom; and 3 Institute for Mathematics and its Applications, University of Minnesota, Minneapolis, Minnesota 55455

We characterized the epicardial activation sequence during a norepinephrine (NE)-induced ventricular arrhythmia in anesthetized pigs and studied factors that modulated it. Subepicardial NE infusion caused the QRS complex to invert within a single beat (n = 35 animals, 101 observations), and the earliest epicardial activation consistently shifted to the randomly located infusion site (n = 14). This preceded right atrial activation, whereas the total ventricular epicardial activation time increased from 20 ± 4 to 50 ± 9 ms (P < 0.01). These events were accompanied by a ventricular tachycardia and a drop in left ventricular pressure, which were fully reversed after the infusion was stopped. Epicardial pacing at the infusion site mimicked all electrical and hemodynamic changes induced by NE. The arrhythmia was prevented by propranolol and abolished by cardiac sympathetic or vagal nerve stimulation. Focal automaticity was computationally reconstructed using a two-dimensional sheet of 256 × 256 resistively coupled ventricular cells, where calcium handling was abnormally high in the central region. We conclude that adrenergic stimulation to a small region of the ventricle elicits triggered automaticity and that computational reconstruction implicates calcium overload. Interventions that reduce spatial inhomogeneities of intracellular calcium may prevent this type of arrhythmia.

catecholamines; cardiac mapping; porcine heart; ventricular arrhythmia


This article has been cited by other articles:


Home page
 Exp PhysiolHome page
M. P. Nash, C. P. Bradley, P. M. Sutton, R. H. Clayton, P. Kallis, M. P. Hayward, D. J. Paterson, and P. Taggart
Whole heart action potential duration restitution properties in cardiac patients: a combined clinical and modelling study
Exp Physiol, March 1, 2006; 91(2): 339 - 354.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. P. Nash, C. P. Bradley, and D. J. Paterson
Imaging Electrocardiographic Dispersion of Depolarization and Repolarization During Ischemia: Simultaneous Body Surface and Epicardial Mapping
Circulation, May 6, 2003; 107(17): 2257 - 2263.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
E. Marret, O. Pruszkowski, A. Deleuze, and F. Bonnet
Accelerated Idioventricular Rhythm Associated with Desflurane Administration
Anesth. Analg., August 1, 2002; 95(2): 319 - 321.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online