Journal of Applied Physiology
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J Appl Physiol 90: 139-146, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 1, 139-146, January 2001

Short-term 17beta -estradiol decreases glucose Ra but not whole body metabolism during endurance exercise

S. Carter1, S. McKenzie2, M. Mourtzakis2, D. J. Mahoney1, and M. A. Tarnopolsky1,2,3

Departments of Medicine (1 Rehabilitation and 3 Neurology) and 2 Kinesiology, McMaster University, Hamilton, Ontario, Canada L8N 3Z5

The female sex hormone 17beta -estradiol (E2) has been shown to increase lipid and decrease carbohydrate utilization in animals. We administrated oral E2 and placebo (randomized, double blind, crossover) to eight human male subjects for 8 days (~3 mg/day) and measured respiratory variables, plasma substrates, hormones (E2, testosterone, leptin, cortisol, insulin, and catecholamines), and substrate utilization during 90 min of endurance exercise. [6,6-2H]glucose and [1,1,2,3,3-2H]glycerol tracers were used to calculate substrate flux. E2 administration increased serum E2 (0.22 to 2.44 nmol/l, P < 0.05) and decreased serum testosterone (19.4 to 11.5 nmol/l, P < 0.05) concentrations, yet there were no treatment effects on any of the other hormones. Glucose rates of appearance (Ra) and disappearance (Rd) were lower, and glycerol Ra-to-Rd ratio was not affected by E2 administration. O2 uptake, CO2 production, and respiratory exchange ratio were not affected by E2; however, there was a decrease in heart rate (P < 0.05). Plasma lactate and glycerol were unaffected by E2; however, glucose was significantly higher (P < 0.05) during exercise after E2 administration. We concluded that short-term oral E2 administration decreased glucose Ra and Rd, maintained plasma glucose homeostasis, but had no effect on substrate oxidation during exercise in men.

gender differences; glycogenolysis


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