Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 90: 133-138, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 1, 133-138, January 2001

Resistance exercise training reduces hypertriglyceridemia in HIV-infected men treated with antiviral therapy

Kevin E. Yarasheski1, Pablo Tebas2, Barbara Stanerson1, Sherry Claxton1, Donna Marin2, Kyongtae Bae3, Michael Kennedy2, Woraphot Tantisiriwat2, and William G. Powderly2

1 Division of Metabolism, Endocrinology and Diabetes, 2 Division of Infectious Diseases, and 3 Department of Radiological Sciences, Washington University Medical School, St. Louis, Missouri 63110

Hypertriglyceridemia, peripheral insulin resistance, and trunk adiposity are metabolic complications recently recognized in people infected with human immunodeficiency virus (HIV) and treated with highly active antiretroviral therapy (HAART). These complications may respond favorably to exercise training. Using a paired design, we determined whether 16 wk of weight-lifting exercise increased muscle mass and strength and decreased fasting serum triglycerides and adipose tissue mass in 18 HIV-infected men. The resistance exercise regimen consisted of three upper and four lower body exercises done for 1-1.5 h/day, 4 days/wk for 64 sessions. Dual-energy X-ray absorptiometry indicated that exercise training increased whole body lean mass 1.4 kg (P = 0.005) but did not reduce adipose tissue mass (P = NS). Axial proton-magnetic resonance imaging indicated that thigh muscle cross-sectional area increased 5-7 cm2 (P < 0.005). Muscle strength increased 23-38% (P < 0.0001) on all exercises. Fasting serum triglycerides were decreased at the end of training (281-204 mg/dl; P = 0.02). These findings imply that resistance exercise training-induced muscle hypertrophy may promote triglyceride clearance from the circulation of hypertriglyceridemic HIV-infected men treated with antiviral therapy.

AIDS; metabolic complications; progressive resistance exercise training; muscle protein mass; lipid metabolism; magnetic resonance imaging


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