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J Appl Physiol 90: 10-16, 2001;
8750-7587/01 $5.00
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Vol. 90, Issue 1, 10-16, January 2001

Denopamine, a beta 1-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs

Tsutomu Sakuma1, Chiharu Tuchihara1, Masanobu Ishigaki1, Kazuhiro Osanai1, Yoshihiro Nambu1, Hirohisa Toga1, Keiji Takahashi1, Nobuo Ohya1, Takayuki Kurihara2, and Michael A. Matthay3

Departments of 1 Pulmonary Medicine and 2 Basic Medical Science, Kanazawa Medical University, Uchinade, Ishikawa 920-0293, Japan; and 3 Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California 94143

The effect of denopamine, a selective beta 1-adrenergic agonist, on alveolar fluid clearance was determined in both ex vivo rat and guinea pig lungs. Alveolar fluid clearance was measured by the progressive increase in the concentration of Evans blue-labeled albumin over 1 h at 37°C. Denopamine (10-6 to 10-3 M) increased alveolar fluid clearance in a dose-dependent manner in ex vivo rat lungs. Denopamine also stimulated alveolar fluid clearance in guinea pig lungs. Atenolol, a selective beta 1-adrenergic antagonist, and amiloride, a sodium channel inhibitor, inhibited denopamine-stimulated alveolar fluid clearance. The potency of denopamine was similar to that of similar doses of isoproterenol or terbutaline. Short-term hypoxia (100% nitrogen for 1-2 h) did not alter the stimulatory effect of denopamine. Denopamine (10-4, 10-3 M) increased intracellular adenosine 3',5'-cyclic monophosphate levels in cultured rat alveolar type II cells. In summary, denopamine, a selective beta 1-adrenergic agonist, stimulates alveolar fluid clearance in both ex vivo rat and guinea pig lungs.

pulmonary edema; sodium transport; alveolar epithelium


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