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J Appl Physiol 9: 481-483, 1956;
8750-7587/56 $5.00
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Metabolism of C14 Histamine in Man

Richard W. Schayer 1 and John A. D. Cooper 1

1 From The Rheumatic Fever Research Institute, and the Department of Biochemistry, Northwestern University Medical School, Chicago, Illinois

Three normal men were injected intradermally with microgram quantities of C14 histamine. Most of the C14 appeared in the urine within 6 hours. Analysis of this urine showed that 1-methylimidazole-4-acetic acid is the principal metabolite, with smaller quantities of 1-ribosylimidazole-4-acetic acid, imidazoleacetic acid, 1-methyl-4-(ß-aminoethyl) imidazole, and unchanged histamine also present. A discussion of the quantitative aspects of the assays is given.

Note:
with the technical assistance of Rosa L. Smiley and K. Jane Davis.

Submitted on June 27, 1956






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