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J Appl Physiol 9: 265-267, 1956;
8750-7587/56 $5.00
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Epinephrine and Mitotic Activity in Pinnal Epidermis of the Mouse

Anand P. Chaudhry 1, Franz Halberg 1, and John J. Bittner 1

1 From the Division of Cancer Biology, Department of Physiology, and the Division of Oral Pathology, University of Minnesota Medical and Dental Schools, Minneapolis, Minnesota

The total number of mitoses and the distribution of mitotic stages were evaluated in pinnal epidermis of two groups of ZBC mice. One group was untreated, the other was given 10ggr of epinephrine/20 gm of body weight at 4 hours prior to being killed. The mice were killed at the daily peak time of mitotic activity. Epinephrine was found to inhibit the total number of mitoses in the pinnal epidermis of the mice studied, in agreement with related studies by Bullough. The analysis of the effect of epinephrine upon the various stages of mitosis did not yield evidence for an interference by epinephrine with the mitotic process per se.

Submitted on April 4, 1956






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