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J Appl Physiol 9: 222-226, 1956;
8750-7587/56 $5.00
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Effect of Antrum Exclusion on Gastric Secretion

William R. Waddell 1

1 From the Departments of Surgery, Massachusetts General Hospital and Harvard Medical School and the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Acid secretory tests were performed on patients before and after vagotomy and antrum exclusion operations for duodenal ulcer. Comparison of the effect of this operation with the effect of vagotomy and gastroenterostomy has allowed evaluation of the function of the intrinsic innervation of the stomach upon acid secretion. Transection of the stomach caused decrease in acid output during basal periods and after stimulation with histamine and insulin. It is concluded that this results from interruption of intrinsic postganglionic parasympathetic innervation which normally passes from the antrum to the parietal cell area in the gastric wall.

Submitted on April 16, 1956






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