Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 89: 2407-2412, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 6, 2407-2412, December 2000

Ventilation-perfusion matching in long-term microgravity

Y. Verbandt1, M. Wantier1, G. K. Prisk2, and M. Paiva1

1 Biomedical Physics Laboratory, Université Libre de Bruxelles, Brussels 1070, Belgium and 2 Department of Medicine, University of California, San Diego, La Jolla, California 92093-0931

We studied the ventilation-perfusion matching pattern in normal gravity (1 G) and short- and long-duration microgravity (µG) using the cardiogenic oscillations in the sulfur hexaflouride (SF6) and CO2 concentration signals during the phase III portion of vital capacity single-breath washout experiments. The signal power of the cardiogenic concentration variations was assessed by spectral analysis, and the phase angle between the oscillations of the two simultaneously expired gases was obtained through cross-correlation. For CO2, a significant reduction of cardiogenic power was observed in µG, with respect to 1 G, but the reduction was smaller and more variable in the case of SF6. A shift from an in-phase condition in 1 G to an out-of-phase condition was found for both short- and long-duration µG. We conclude that, although the distribution of ventilation and perfusion becomes more homogeneous in µG, significant inhomogeneities persist and that areas of high perfusion become associated with areas of relatively lower ventilation. In addition, these modifications seem to remain constant during long-term exposure to µG.

ventilation-perfusion ratio; cardiogenic oscillations; long-duration microgravity.


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